AiPD: Autoinhibited Protein Database

Gene name	FRE6 (YLL051C, L0593)
Protein name	Ferric reductase transmembrane component 6
Names	Ferric-chelate reductase 6
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YLL051C
EC number	1.16.1.9: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

88-169 (Predicted disordered autoinhibitory region) PR

88-169 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q12473-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s12-39311	54	V>L	No	SGRP
s12-39123	116	E>D	No	SGRP
s12-39068	135	S>P	No	SGRP
s12-38935	179	V>A	No	SGRP
s12-38564	303	A>T	No	SGRP
s12-38538	311	L>F	No	SGRP
s12-38183	430	L>I	No	SGRP
s12-37936	512	S>N	No	SGRP
s12-37883	530	L>V	No	SGRP
s12-37833	546	H>Q	No	SGRP
s12-37819	551	D>G	No	SGRP
s12-37712	587	A>T	No	SGRP
s12-37649	608	R>G	No	SGRP
s12-37622	617	L>I	No	SGRP
s12-37610	621	T>A	No	SGRP
s12-37551	640	M>I	No	SGRP
s12-37529	648	H>Y	No	SGRP
s12-37508	655	N>D	No	SGRP
s12-37447	675	V>A	No	SGRP
s12-37448	675	V>I	No	SGRP
s12-37448	675	V>L	No	SGRP

Type	Name	Position	InterPro Accession
conserved_site	Actinin-type actin-binding domain, conserved site	213 - 237	IPR001589
domain	Calponin homology domain	124 - 241	IPR001715-1
domain	Calponin homology domain	269 - 372	IPR001715-2
domain	Calponin homology domain	393 - 499	IPR001715-3
domain	Calponin homology domain	514 - 622	IPR001715-4

		Description
EC Number	1.16.1.9	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Vacuole membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
fungal-type vacuole	A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
fungal-type vacuole membrane	The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ferric-chelate reductase (NADPH) activity	Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH.
ferric-chelate reductase activity	Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
metal ion binding	Binding to a metal ion.

Name	Definition
cellular iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
copper ion import	The directed movement of copper ions into a cell or organelle.
intracellular sequestering of iron ion	The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
iron ion transport	The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins