Q12445

PR
Gene name
POM34 (YLR018C)
Protein name
Nucleoporin POM34
Names
Nuclear pore protein POM34, Pore membrane protein POM34
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR018C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q12445

Entry ID Method Resolution Chain Position Source
8T9L EM 700 A A/C 1-299 PDB
AF-Q12445-F1 Predicted AlphaFoldDB

6 variants for Q12445

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-179275 111 L>V No SGRP
s12-179249 119 H>Q No SGRP
s12-179194 138 I>V No SGRP
s12-179120 162 D>E No SGRP
s12-179028 193 I>T No SGRP
s12-178812 265 N>S No SGRP

No associated diseases with Q12445

No regional properties for Q12445

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q12445

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane; Multi-pass membrane protein
  • Central core structure of the nuclear pore complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of nuclear outer membrane The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nuclear pore transmembrane ring A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.

1 GO annotations of molecular function

Name Definition
structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

5 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear pore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore.
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
spindle pole body duplication Construction of a new spindle pole body.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIQAGQLGL DDNDVPGPLP DTDSKPSSQS QNDTPMFKLG NFESPVLKEL SRRTVNKEME
70 80 90 100 110 120
TQRIMTNVIA FAFWNLLVKF IKFFWNNTHV GRQFCNRLSR IHLYMLTFHT LKKANIIYHT
130 140 150 160 170 180
TFSWLNAELL DYLFHLLISL NILFSLWKLL STVKVSDLNL TDRQKKLLGV DMQSSVDTGL
190 200 210 220 230 240
QPQHPHYVST SKISQMAQNK THIPQTNLKN HPAYLFKGLE TPLKARQREM AEEQTKLQSQ
250 260 270 280 290
SLHTKNVFGT LQRHSGISST LVSANNDNNS PHTPVTRKGY IPSSKYAYMM NSQSPRGKI