AiPD: Autoinhibited Protein Database

Gene name	FRE7 (YOL152W, AOB629)
Protein name	Ferric/cupric reductase transmembrane component 7
Names	Ferric-chelate reductase 7
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YOL152W
EC number	1.16.1.9: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

486-564 (Predicted disordered autoinhibitory region) PR

486-564 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q12333-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s15-40847	34	A>V	No	SGRP
s15-41026	94	T>A	No	SGRP
s15-41254	170	P>S	No	SGRP
s15-41377	211	H>Y	No	SGRP
s15-41410	222	E>K	No	SGRP
s15-41787	347	E>D	No	SGRP
s15-41837	364	G>D	No	SGRP
s15-41837	364	G>V	No	SGRP
s15-41875	377	A>T	No	SGRP
s15-41956	404	M>V	No	SGRP
s15-41966	407	I>T	No	SGRP
s15-41969	408	L>H	No	SGRP
s15-41992	416	I>V	No	SGRP
s15-42008	421	R>K	No	SGRP
s15-42091	449	L>F	No	SGRP
s15-42111	455	E>D	No	SGRP
s15-42164	473	R>K	No	SGRP
s15-42174	476	M>I	No	SGRP
s15-42218	491	K>T	No	SGRP
s15-42239	498	V>A	No	SGRP
s15-42266	507	I>T	No	SGRP
s15-42277	511	F>L	No	SGRP
s15-42289	515	I>L	No	SGRP
s15-42290	515	I>T	No	SGRP
s15-42289	515	I>V	No	SGRP
s15-42333	529	K>N	No	SGRP
s15-42371	542	S>L	No	SGRP
s15-42535	597	G>S	No	SGRP

Type	Name	Position	InterPro Accession
domain	FAD-binding 8	327 - 414	IPR013112
domain	Ferric reductase, NAD binding domain	423 - 595	IPR013121
domain	Ferric reductase transmembrane component-like domain	161 - 280	IPR013130
domain	FAD-binding domain, ferredoxin reductase-type	321 - 419	IPR017927

		Description
EC Number	1.16.1.9	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ferric-chelate reductase (NADPH) activity	Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH.
ferric-chelate reductase activity	Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor.
metal ion binding	Binding to a metal ion.

Name	Definition
copper ion import	The directed movement of copper ions into a cell or organelle.
iron ion transport	The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
reductive iron assimilation	A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins