Q12311
Gene name |
NTO1 (YPR031W) |
Protein name |
NuA3 HAT complex component NTO1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR031W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12311
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12311-F1 | Predicted | AlphaFoldDB |
16 variants for Q12311
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-631524 | 5 | S>A | No | SGRP | |
| s16-631628 | 39 | E>D | No | SGRP | |
| s16-631828 | 106 | N>S | No | SGRP | |
| s16-631839 | 110 | V>I | No | SGRP | |
| s16-631855 | 115 | S>T | No | SGRP | |
| s16-631941 | 144 | A>T | No | SGRP | |
| s16-631983 | 158 | I>V | No | SGRP | |
| s16-632142 | 211 | I>V | No | SGRP | |
| s16-632941 | 477 | T>K | No | SGRP | |
| s16-632954 | 481 | F>L | No | SGRP | |
| s16-633135 | 542 | F>V | No | SGRP | |
| s16-633254 | 581 | K>N | No | SGRP | |
| s16-633262 | 584 | Q>R | No | SGRP | |
| s16-633513 | 668 | G>S | No | SGRP | |
| s16-633642 | 711 | I>V | No | SGRP | |
| s16-633667 | 719 | P>L | No | SGRP |
No associated diseases with Q12311
3 regional properties for Q12311
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B3 DNA binding domain | 21 - 118 | IPR003340-1 |
| domain | B3 DNA binding domain | 140 - 236 | IPR003340-2 |
| domain | B3 DNA binding domain | 320 - 427 | IPR003340-3 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| MOZ/MORF histone acetyltransferase complex | A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. |
| NuA3 histone acetyltransferase complex | A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p. |
| NuA3a histone acetyltransferase complex | A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p. |
| NuA3b histone acetyltransferase complex | A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| histone acetylation | The modification of a histone by the addition of an acetyl group. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95696 | BRD1 | Bromodomain-containing protein 1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRGSLDDGP | KLREEKHFQD | FYPDLNADTL | LPFIVPLVET | KDNSTDTDSD | DISNRNNREI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSVKSVQTKE | LIFKGRVTTE | PLVLKKNEVE | FQKCKITTNE | LKGKKNPYCV | RFNESFISRY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YHINKVRNRK | SYKQQQKEFD | GVEAPYFTKF | SSKEAPNITI | STSTKSAIQK | FASISPNLVN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKPQYDMDEQ | DELYLHYLNK | RYFKDQMSHE | IFEILMTTLE | TEWFHIEKHI | PSTNSLIARH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NILRDCKNYE | LYGSDDGTGL | SMDQACAVCL | GTDSDNLNTI | VFCDGCDIAV | HQECYGIIFI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PEGKWLCRRC | MISKNNFATC | LMCPSHTGAF | KQTDTGSWVH | NICALWLPEL | YFSNLHYMEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IEGVQNVSVS | RWKLNCYICK | KKMGACIQCF | QRNCFTAYHV | TCARRAGLYM | SKGKCTIQEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASNQFSQKYS | VESFCHKHAP | RGWQTSIEGI | NKARKYFSLL | STLQTETPQH | NEANDRTNSK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FNKTIWKTPN | QTPVAPHVFA | EILQKVVDFF | GLANPPAGAF | DICKYWSMKR | ELTGGTPLTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CFENNSLGSL | TEEQVQTRID | FANDQLEDLY | RLKELTTLVK | KRTQASNSLS | RSRKKVFDIV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KSPQKYLLKI | NVLDIFIKSE | QFKALERLVT | EPKLLVILEK | CKHCDFDTVQ | IFKEEIMHFF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EVLETLPGAS | RILQTVSSKA | KEQVTNLIGL | IEHVDIKKLL | SRDFIINDDK | IEERPWSGPV |
| 730 | 740 | ||||
| IMEEEGLSDA | EELSAGEHRM | LKLILNSG |