Q12297
Gene name |
TAF3 (TAF47, YPL011C, LPA6C) |
Protein name |
Transcription initiation factor TFIID subunit 3 |
Names |
TAFII-47, TAFII47, TBP-associated factor 3, TBP-associated factor 47 kDa |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL011C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12297
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12297-F1 | Predicted | AlphaFoldDB |
8 variants for Q12297
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-534424 | 93 | S>A | No | SGRP | |
| s16-534398 | 101 | M>I | No | SGRP | |
| s16-534359 | 114 | L>F | No | SGRP | |
| s16-534255 | 149 | L>Q | No | SGRP | |
| s16-533817 | 295 | N>S | No | SGRP | |
| s16-533775 | 309 | E>G | No | SGRP | |
| s16-533749 | 318 | I>L | No | SGRP | |
| s16-533644 | 353 | F>L | No | SGRP |
No associated diseases with Q12297
1 regional properties for Q12297
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Bromodomain associated domain | 5 - 83 | IPR006565 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| RNA polymerase II preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTNNDFYFA | LLRISILQLL | KAQGFDRARP | SLVDVMTDLY | AKFLSLLASE | VSSIAQARCD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDDTIALQDI | TLALENLGIV | KPTNVLDVYD | ENSELSSSRG | MEKFKDWCIY | STQLTDARIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALPTVELLQS | EEKESDPLSA | IPDYLNQLLQ | NKGAKQKLET | KNRKTELIED | LINNNGLDDW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKLVIARQRI | NMIERASKKE | SQNVPALPHI | AGYKSSILSR | HHHTTITNED | RMPSAMTPRD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDALTEIQEN | PFVTSKLPIM | RKENRLENIT | LSFEDEELES | LGEVEGPNQK | SQENNNEESF |
| 310 | 320 | 330 | 340 | 350 | |
| KENNKSLTES | PHGDDRDISM | FQFDSNVDTK | WAEQEDMDST | FQRRTSLDYG | GYF |