Q12262

PR
Gene name
MCM16 (YPR046W)
Protein name
Inner kinetochore subunit MCM16
Names
CENP-H homolog, Constitutive centromere-associated network protein MCM16, Minichromosome maintenance protein 16
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR046W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for Q12262

Entry ID Method Resolution Chain Position Source
6OUA EM 418 A H 1-181 PDB
6QLD EM 415 A H 4-136 PDB
6QLE EM 355 A H 1-136 PDB
6WUC EM 323 A H 1-181 PDB
6YPC X-ray 290 A H 137-181 PDB
7L7Q EM 370 A H 1-181 PDB
8OVW EM 340 A H 1-181 PDB
8OW0 EM 340 A H 1-181 PDB
8OW1 EM 370 A H/HH 1-181 PDB
AF-Q12262-F1 Predicted AlphaFoldDB

4 variants for Q12262

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-656908 38 K>R No SGRP
s16-656945 50 Q>H No SGRP
s16-657148 118 R>K No SGRP
s16-657228 145 S>G No SGRP

No associated diseases with Q12262

No regional properties for Q12262

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q12262

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere, kinetochore
  • Associated with kinetochores
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
attachment of spindle microtubules to kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
establishment of mitotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTNSSEKQWE RIQQLEKEHV EVYRELLITL DRLYLIRKHN HAVILSHTQQ RLLEIRHQLQ
70 80 90 100 110 120
INLEKTALLI RLLEKPDNTN VLFTKLQNLL EESNSLDYEL LQSLGAQSSL HKQLIESRAE
130 140 150 160 170 180
RDELMSKLIE LSSKFPKPTI PPDDSDTAGK QVEVEKENET IQELMIALQI HSGYTNISYT
I