Q12255
Gene name |
NYV1 (MAM2, YLR093C) |
Protein name |
Vacuolar v-SNARE NYV1 |
Names |
R-SNARE NYV1, New v-SNARE 1, Synaptobrevin NYV1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR093C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q12255
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2FZ0 | NMR | - | A | 1-149 | PDB |
| AF-Q12255-F1 | Predicted | AlphaFoldDB |
3 variants for Q12255
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-326976 | 100 | M>I | No | SGRP | |
| s12-326930 | 116 | E>K | No | SGRP | |
| s12-326765 | 171 | T>S | No | SGRP |
No associated diseases with Q12255
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vacuolar calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings. |
| vacuole fusion, non-autophagic | The fusion of two vacuole membranes to form a single vacuole. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
| vesicle fusion to plasma membrane | Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QI5 | VAMP7 | Vesicle-associated membrane protein 7 | Bos taurus (Bovine) | SS |
| Q5ZL74 | VAMP7 | Vesicle-associated membrane protein 7 | Gallus gallus (Chicken) | SS |
| P51809 | VAMP7 | Vesicle-associated membrane protein 7 | Homo sapiens (Human) | EV |
| P70280 | Vamp7 | Vesicle-associated membrane protein 7 | Mus musculus (Mouse) | SS |
| Q9JHW5 | Vamp7 | Vesicle-associated membrane protein 7 | Rattus norvegicus (Rat) | SS |
| Q9M376 | VAMP727 | Vesicle-associated membrane protein 727 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LFP1 | VAMP713 | Vesicle-associated membrane protein 713 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SIQ9 | VAMP712 | Vesicle-associated membrane protein 712 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49377 | VAMP711 | Vesicle-associated membrane protein 711 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FMR5 | VAMP714 | Vesicle-associated membrane protein 714 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRFNVSYVE | VIKNGETISS | CFQPFQKNEN | YGTITSANEQ | ITPVIFHNLI | MDMVLPKVVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKGNKVTKMS | MNLIDGFDCF | YSTDDHDPKT | VYVCFTLVDM | PKILPIRILS | GLQEYESNAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NELLSSHVGQ | ILDSFHEELV | EYRNQTLNSS | GNGQSSNGNG | QNTISDIGDA | TEDQIKDVIQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IMNDNIDKFL | ERQERVSLLV | DKTSQLNSSS | NKFRRKAVNI | KEIMWWQKVK | NITLLTFTII |
| 250 | |||||
| LFVSAAFMFF | YLW |