Q12214

PR
Gene name
HOS1 (YPR068C, YP9499.23C)
Protein name
Histone deacetylase HOS1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR068C
EC number
3.5.1.98: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12214

Entry ID Method Resolution Chain Position Source
AF-Q12214-F1 Predicted AlphaFoldDB

10 variants for Q12214

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-684188 55 D>H No SGRP
s16-684161 64 S>P No SGRP
s16-683890 154 T>I No SGRP
s16-683887 155 Y>C No SGRP
s16-683500 284 S>N No SGRP
s16-683293 353 I>T No SGRP
s16-683282 357 I>V No SGRP
s16-683161 397 L>S No SGRP
s16-683069 428 V>I No SGRP
s16-683022 443 M>I No SGRP

No associated diseases with Q12214

4 regional properties for Q12214

Type Name Position InterPro Accession
conserved_site Helix-turn-helix motif 49 - 74 IPR000047
domain Homeobox domain 17 - 82 IPR001356
domain Leucine zipper, homeobox-associated 78 - 120 IPR003106
conserved_site Homeobox, conserved site 53 - 76 IPR017970

Functions

Description
EC Number 3.5.1.98 In linear amides
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
histone deacetylase complex A protein complex that possesses histone deacetylase activity.

2 GO annotations of molecular function

Name Definition
histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
protein lysine deacetylase activity Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-

4 GO annotations of biological process

Name Definition
histone deacetylation The modification of histones by removal of acetyl groups.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transfer RNA gene-mediated silencing The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF
70 80 90 100 110 120
HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN WNEKIDYNPS QDLQRFTTRE
130 140 150 160 170 180
NLYNYYLNHS QALENNMDCI NNSEVPTNDK PTDTYILNSE TKQYNLEGDC PIFSYLPMYC
190 200 210 220 230 240
QVITGATLNL LDHLSPTERL IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK
250 260 270 280 290 300
ITYVDFDLHH GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG
310 320 330 340 350 360
CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL SRIIINIMKS
370 380 390 400 410 420
YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG DNNSFQIDPF DVCDGDDSEQ
430 440 450 460
FIREHDLVEM YNEENYQYWI YEMEGSSRMK MLRNDNKDRD MVELMKFYEL