AiPD: Autoinhibited Protein Database

Gene name	YLL058W (L0569)
Protein name	Putative cystathionine gamma-synthase YLL058W
Names	O-succinylhomoserine (thiol)-lyase
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YLL058W
EC number	2.5.1.47: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

71-210 (Predicted disordered autoinhibitory region) PR

71-210 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q12198-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s12-23774	69	G>D	No	SGRP
s12-23820	84	K>N	No	SGRP
s12-23826	86	F>L	No	SGRP
s12-23846	93	S>*	No	SGRP
s12-23846	93	S>L	No	SGRP
s12-23845	93	S>T	No	SGRP
s12-23860	98	K>E	No	SGRP
s12-23890	108	I>V	No	SGRP
s12-23900	111	R>H	No	SGRP
s12-23905	113	A>T	No	SGRP
s12-23959	131	A>T	No	SGRP
s12-23981	138	T>I	No	SGRP
s12-24010	148	E>K	No	SGRP
s12-24085	173	L>M	No	SGRP
s12-24110	181	F>S	No	SGRP
s12-24164	199	V>A	No	SGRP
s12-24179	204	R>K	No	SGRP
s12-24188	207	G>D	No	SGRP
s12-24323	252	S>L	No	SGRP
s12-24356	263	Q>P	No	SGRP
s12-24473	302	R>K	No	SGRP
s12-24567	333	M>I	No	SGRP
s12-24591	341	S>R	No	SGRP
s12-24890	441	G>E	No	SGRP
s12-24893	442	I>K	No	SGRP
s12-24926	453	G>E	No	SGRP
s12-24967	467	K>E	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q12198

		Description
EC Number	2.5.1.47	Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
cystathionine gamma-synthase activity	Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.
cystathionine gamma-synthase activity (acts on O-phosphohomoserine)	Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate.
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Name	Definition
methionine biosynthetic process	The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
sulfur compound metabolic process	The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
transsulfuration	The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins