Q12136
PR
Gene name |
SAS10 (UTP3, YDL153C, D1545) |
Protein name |
Something about silencing protein 10 |
Names |
U three protein 3, U3 small nucleolar RNA-associated protein 3, U3 snoRNA-associated protein 11 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL153C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
25 structures for Q12136
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5WLC | EM | 380 A | NB | 1-610 | PDB |
| 6KE6 | EM | 340 A | 5H | 1-610 | PDB |
| 6LQP | EM | 320 A | 5H | 1-610 | PDB |
| 6LQQ | EM | 410 A | 5H | 1-610 | PDB |
| 6LQR | EM | 860 A | 5H | 1-610 | PDB |
| 6LQS | EM | 380 A | 5H | 1-610 | PDB |
| 6LQT | EM | 490 A | 5H | 1-610 | PDB |
| 6LQU | EM | 370 A | 5H | 1-610 | PDB |
| 6LQV | EM | 480 A | 5H | 1-610 | PDB |
| 6ZQA | EM | 440 A | UC | 1-610 | PDB |
| 6ZQB | EM | 390 A | UC | 1-610 | PDB |
| 6ZQC | EM | 380 A | UC | 1-610 | PDB |
| 6ZQD | EM | 380 A | UC | 1-610 | PDB |
| 6ZQE | EM | 710 A | UC | 1-610 | PDB |
| 6ZQF | EM | 490 A | UC | 1-610 | PDB |
| 6ZQG | EM | 350 A | UC | 1-610 | PDB |
| 7AJT | EM | 460 A | UC | 1-610 | PDB |
| 7AJU | EM | 380 A | UC | 1-610 | PDB |
| 7D4I | EM | 400 A | 5H | 1-610 | PDB |
| 7D5S | EM | 460 A | 5H | 1-610 | PDB |
| 7D5T | EM | 600 A | 5H | 1-610 | PDB |
| 7D63 | EM | 1230 A | 5H | 1-610 | PDB |
| 7SUK | EM | 399 A | NB | 431-610 | PDB |
| 7WTL | EM | 330 A | UC | 1-610 | PDB |
| AF-Q12136-F1 | Predicted | AlphaFoldDB |
15 variants for Q12136
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-183012 | 3 | R>H | No | SGRP | |
| s04-182904 | 39 | G>E | No | SGRP | |
| s04-182863 | 53 | S>P | No | SGRP | |
| s04-182601 | 140 | A>G | No | SGRP | |
| s04-182499 | 174 | V>A | No | SGRP | |
| s04-182359 | 221 | A>T | No | SGRP | |
| s04-182311 | 237 | L>I | No | SGRP | |
| s04-182082 | 313 | G>D | No | SGRP | |
| s04-182020 | 334 | Q>E | No | SGRP | |
| s04-181989 | 344 | G>E | No | SGRP | |
| s04-181979 | 347 | Q>H | No | SGRP | |
| s04-181935 | 362 | E>G | No | SGRP | |
| s04-181936 | 362 | E>K | No | SGRP | |
| s04-181860 | 387 | T>R | No | SGRP | |
| s04-181314 | 569 | Y>F | No | SGRP |
No associated diseases with Q12136
1 regional properties for Q12136
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sas10 C-terminal domain | 535 - 608 | IPR018972 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVRKGSNRTK | TSEVGDEINP | YGLNEVDDFA | SKREKVLLGQ | STFGDSNKDD | DHSLLEDEDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEVLAMDEDD | ESIDEREDEE | EEEEEELDGA | AAYKKIFGRN | LETDQLPEED | EENGMLDNEN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AWGSTKGEYY | GADDLDDDEA | AKEIEKEALR | QQKKHLEELN | MNDYLDEEEE | EEWVKSAKEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DMGEFKNSTK | QADTKTSITD | ILNMDDEARD | NYLRTMFPEF | APLSKEFTEL | APKFDELKKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EENEFNKLKL | IALGSYLGTI | SCYYSILLHE | LHNNEDFTSM | KGHPVMEKIL | TTKEIWRQAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELPSSFDVNE | GDGSESEETA | NIEAFNEKKL | NELQNSEDSD | AEDGGKQKQE | IDEEERESDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEEEEDVDID | DFEEYVAQSR | LHSKPKTSSM | PEADDFIESE | IADVDAQDKK | ARRRTLRFYT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SKIDQQENKK | TDRFKGDDDI | PYKERLFERQ | QRLLDEARKR | GMHDNNGADL | DDKDYGSEDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AVSRSINTQG | ENDYYQQVQR | GKQDKKISRK | EAHKNAVIAA | REGKLAELAE | NVSGDGKRAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NYQILKNKGL | TPKRNKDNRN | SRVKKRKKYQ | KAQKKLKSVR | AVYSGGQSGV | YEGEKTGIKK |
| GLTRSVKFKN |