Q12106
Gene name |
MCP1 |
Protein name |
Mitochondrial adapter protein MCP1 |
Names |
MDM10-complementing protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR228C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12106
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12106-F1 | Predicted | AlphaFoldDB |
10 variants for Q12106
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-767757 | 8 | P>S | No | SGRP | |
| s15-767624 | 52 | R>K | No | SGRP | |
| s15-767402 | 126 | N>S | No | SGRP | |
| s15-767378 | 134 | R>K | No | SGRP | |
| s15-767292 | 163 | G>R | No | SGRP | |
| s15-767238 | 181 | V>F | No | SGRP | |
| s15-767206 | 191 | M>I | No | SGRP | |
| s15-767199 | 194 | V>L | No | SGRP | |
| s15-767094 | 229 | I>L | No | SGRP | |
| s15-766911 | 290 | S>G | No | SGRP |
No associated diseases with Q12106
2 regional properties for Q12106
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Mitochondrial adapter protein MCP1, transmembrane domain | 68 - 167 | IPR012472-1 |
| domain | Mitochondrial adapter protein MCP1, transmembrane domain | 182 - 275 | IPR012472-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial membrane | The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid homeostasis | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| protein localization to mitochondrion | A process in which a protein is transported to, or maintained in, a location within the mitochondrion. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIKLHEVPPE | PVDPASLPHD | VNAHSPEGDG | NPDKRKKIFG | IPYPFSRSSC | RRFLWNCQKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVLPMALYFP | LHAANTLITP | AVSPDSAPDD | VLMMVREILP | SITTKLLVAG | ITLHVSAGVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRIVNNWNKP | RRNRHRHLKI | SAEQDLSQDS | IGLTGGISGY | LFGLYKTFRI | PPQVISGYIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VPVLIYHLLI | MKWVPNSIST | EVDFASIKQL | LSSKNRWWKW | LGGLVPLAIL | LESGVYHIGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLCRYFGVRK | MTSRKKWSTA | INLLTLVGFV | SLIRLMKEDS | TKLGPNQFES | IFKKIRLLLH |
| VN |