Q12098

PR
Gene name
SLX4
Protein name
Structure-specific endonuclease subunit SLX4
Names
Synthetic lethal of unknown function protein 4
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR135W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-448 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q12098

Entry ID Method Resolution Chain Position Source
6J0Y X-ray 180 A C/D 535-587 PDB
7CQ2 X-ray 250 A C/D 610-747 PDB
7CQ3 X-ray 145 A B 675-748 PDB
7CQ4 X-ray 329 A B 610-748 PDB
AF-Q12098-F1 Predicted AlphaFoldDB

25 variants for Q12098

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-413315 12 F>L No SGRP
s12-413453 58 G>S No SGRP
s12-413494 71 M>I No SGRP
s12-413572 97 H>Q No SGRP
s12-413586 102 G>E No SGRP
s12-413600 107 E>K No SGRP
s12-413616 112 N>S No SGRP
s12-413639 120 D>H No SGRP
s12-413703 141 S>I No SGRP
s12-413735 152 N>D No SGRP
s12-413837 186 D>N No SGRP
s12-413868 196 R>K No SGRP
s12-413958 226 P>L No SGRP
s12-414123 281 N>S No SGRP
s12-414359 360 N>D No SGRP
s12-414414 378 L>Q No SGRP
s12-414437 386 A>P No SGRP
s12-414770 497 V>I No SGRP
s12-414994 571 E>D No SGRP
s12-415109 610 S>P No SGRP
s12-415113 611 A>E No SGRP
s12-415280 667 P>S No SGRP
s12-415315 678 N>K No SGRP
s12-415400 707 P>S No SGRP
s12-415521 747 K>R No SGRP

No associated diseases with Q12098

No regional properties for Q12098

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q12098

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endonuclease complex A protein complex which is capable of endonuclease activity.
nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Slx1-Slx4 complex A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes.

1 GO annotations of molecular function

Name Definition
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.

10 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
double-strand break repair via single-strand annealing, removal of nonhomologous ends During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur.
interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
regulation of DNA damage checkpoint Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.
regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing.
regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.
regulation of replication fork arrest at rDNA repeats Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELQRAQRNL KFLQNEDYVN VTDQTNLNGE SQNAYSLGME TQVPEMQFSL SSDDDSIGTQ
70 80 90 100 110 120
VKSVTAQKSP MTQETTKNDT ERNKDVDKSC NPVSTSHPDL GGSNIEENIF INTQIQSRLD
130 140 150 160 170 180
DAEEETNLKL KLEKFKYSFK SSNADDTHSN ANVTAKRRPA IRKANSKLKT KPKTKRDPKI
190 200 210 220 230 240
IKNITDFNIN NYERSRTASL LKQLSGKHKK VLDIIKTQNE GNSDKPPRAR NNKGEKATFD
250 260 270 280 290 300
TYSEQEWKDI MKLLLQKFPQ SEETDLNEVQ KFLYGSEKSS NSLDNQESSQ QRLWTASQLP
310 320 330 340 350 360
PELPDEAIQP EQEERIRDTQ SAVNFLSLSQ VMDDKSEIMK DEESIIISRG DSTSSQEYGN
370 380 390 400 410 420
GLEPQQPVGN VVGEDIELAV GTRINAFSLT DYKACKPMSV EVSRRCENST DNDYDNISIV
430 440 450 460 470 480
SDTTDETSTL FPLDQYRYVF IENDERPPLA TDTIGSTQFF TPNTSPLDGI IDLTQESFKA
490 500 510 520 530 540
VRSLISPLKV ENNKTGVTSQ ASNQVQVPAT RTPTIIPQKN LTTTLKTEEE KNNIGSSIRV
550 560 570 580 590 600
KLLQESVVKL NPKLVKHNFY RVEANDSEEE ETEFDDQFCI ADIQLVDSSK ISTKDSTQNP
610 620 630 640 650 660
TTSNDIIDTS AASSIASPEK FCEIMMSQSM KELRQSLKTV GLKPMRTKVE IIQSLQTASQ
670 680 690 700 710 720
ILSTANPDNK GEHGGVANFS KIEIFDHLTE LIEAFPDFLE RIYTFEPIPL NELIEKLFSA
730 740
EPFVSQIDEM TIREWADVQG ICLRNDKK