Q12052

PR
Gene name
TGS1 (YPL157W, P2573)
Protein name
Trimethylguanosine synthase
Names
Cap-specific guanine-N2 methyltransferase, snRNA/snoRNA cap hypermethylase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL157W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

239-315 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12052

Entry ID Method Resolution Chain Position Source
AF-Q12052-F1 Predicted AlphaFoldDB

7 variants for Q12052

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-254973 54 K>R No SGRP
s16-255111 100 R>K No SGRP
s16-255174 121 Y>C No SGRP
s16-255428 206 S>G No SGRP
s16-255695 295 K>E No SGRP
s16-255725 305 D>N No SGRP
s16-255749 313 V>L No SGRP

No associated diseases with Q12052

No regional properties for Q12052

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q12052

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
RNA trimethylguanosine synthase activity Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine.

7 GO annotations of biological process

Name Definition
7-methylguanosine cap hypermethylation Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.
7-methylguanosine RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
nucleologenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.
regulation of telomere maintenance via telomerase Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.
RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGRTFIHASK IKHAARKRKH HSNFRTLIKL LNNDAYKIES SKPLKNGKLF KYWKNRRRLF
70 80 90 100 110 120
SKIDSASIYM TDELWFSVTP ERIACFLANF VKACMPNAER ILDVFCGGGG NTIQFAMQFP
130 140 150 160 170 180
YVYGVDYSIE HIYCTAKNAQ SYGVDDRIWL KRGSWKKLVS KQKLSKIKYD CVFGSPPWGG
190 200 210 220 230 240
PEYLRNDVYD LEQHLKPMGI TKMLKSFLKL SPNVIMFLPR NSDLNQLSRA TRKVLGPFAK
250 260 270 280 290 300
CKVLYVKENG YMKGIFCMWG ECFFNYEPAS TENSRRESSE KEELSSENEE LSKRKKHEST
310
TTTKDNTVDI YDVNG