Q12013
Gene name |
AKR2 (YOR034C, OR26.25) |
Protein name |
Probable palmitoyltransferase AKR2 |
Names |
Ankyrin repeat-containing protein AKR2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR034C |
EC number |
2.3.1.225: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12013
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12013-F1 | Predicted | AlphaFoldDB |
26 variants for Q12013
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-397029 | 20 | A>S | No | SGRP | |
| s15-396839 | 83 | D>G | No | SGRP | |
| s15-396774 | 105 | L>F | No | SGRP | |
| s15-396750 | 113 | A>T | No | SGRP | |
| s15-396696 | 131 | I>V | No | SGRP | |
| s15-396630 | 153 | N>D | No | SGRP | |
| s15-396447 | 214 | S>A | No | SGRP | |
| s15-396438 | 217 | A>T | No | SGRP | |
| s15-396098 | 330 | L>P | No | SGRP | |
| s15-395871 | 406 | V>F | No | SGRP | |
| s15-395868 | 407 | V>L | No | SGRP | |
| s15-395820 | 423 | D>N | No | SGRP | |
| s15-395690 | 466 | G>D | No | SGRP | |
| s15-395649 | 480 | Y>H | No | SGRP | |
| s15-395393 | 565 | L>S | No | SGRP | |
| s15-395321 | 589 | H>R | No | SGRP | |
| s15-395279 | 603 | I>T | No | SGRP | |
| s15-395268 | 607 | E>K | No | SGRP | |
| s15-395238 | 617 | I>V | No | SGRP | |
| s15-395171 | 639 | N>I | No | SGRP | |
| s15-395160 | 643 | A>T | No | SGRP | |
| s15-395093 | 665 | V>A | No | SGRP | |
| s15-395073 | 672 | H>D | No | SGRP | |
| s15-395073 | 672 | H>Y | No | SGRP | |
| s15-394994 | 698 | T>M | No | SGRP | |
| s15-394932 | 719 | D>N | No | SGRP |
No associated diseases with Q12013
3 regional properties for Q12013
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Palmitoyltransferase, DHHC domain | 442 - 580 | IPR001594 |
| repeat | Ankyrin repeat | 49 - 149 | IPR002110-1 |
| repeat | Ankyrin repeat | 150 - 254 | IPR002110-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.225 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (CH3-14-CO-) group to an acceptor molecule. |
| protein-cysteine S-palmitoyltransferase activity | Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl- |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein palmitoylation | The covalent attachment of a palmitoyl group to a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39010 | AKR1 | Palmitoyltransferase AKR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSMSIIDDE | NVKKTSNGAA | VVTDVAQHAV | SDSDNNKAQL | LGDGSNTEYV | VDIFIEAAKD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDLKVVKDVV | ESGAVDINND | RIDELSGLHW | ACINNRFSVA | KFLLLRGANP | NQAAGPGGAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALHWAARYGN | IYIVDLLLKH | GADPTLKDEQ | GLNIMHFSVY | SSNILLVVYV | LYFVVNNNDN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDIDSKDNNN | RTPLLWAAYQ | GDFLTVELLL | KFGSTVAWTD | NRGFNALHCA | LVGGDQRVIC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLILSGANFY | ERNNQKQDCF | DLAEGMGTKS | LFEQALQHHG | YDRLGNQKDK | LFKKSSHAQF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TIFLSPFLLM | VYIYLISLVL | SPVLAIMLSL | LVTVVMVNTL | KKFVLPCLPR | KNTYKVSLTR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TPFFSGLFLS | TFCFLIYIWT | KKLYPYSVSD | YTMKNVQFLV | TSFLTVVLFL | RLVRSDPGCL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTDDSLTSIQ | ETIKQLIDLG | KFDRENFCVE | TLERKPLRSK | YSFFSGALVA | RYDHYCPWIY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDVGLKNHKL | FVFFAVTVQY | HMFLFMWLCL | AYFKKTNYIY | EQVEEYARCA | LLKNETLCKG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SNYDPSTFFL | FIWISVNFIW | LGAMLIVQFF | QILKGITTPE | LFILIKEEHK | AKFINLIPFE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSIYTSESKG | VEDSDMIPEG | PSATTITHTI | SIDGLEPRNR | RRAILSACFS | MMGINQWLVT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IKEIVGITHI | LHGQVPQQHH | SSLLRSFLVT | NHWKTNLTDF | WLNSDVTAPL | WQRFFYSSDT |
| 730 | 740 | ||||
| SKAMLGGTEV | DYYELYEYPA | REGEVLRPN |