Q12010
Gene name |
YPQ1 (YOL092W, O0929) |
Protein name |
Probable vacuolar amino acid transporter YPQ1 |
Names |
PQ-loop repeat-containing protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL092W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q12010
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q12010-F1 | Predicted | AlphaFoldDB |
7 variants for Q12010
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-144354 | 51 | V>I | No | SGRP | |
| s15-144574 | 124 | E>V | No | SGRP | |
| s15-144642 | 147 | S>T | No | SGRP | |
| s15-144655 | 151 | A>V | No | SGRP | |
| s15-144657 | 152 | G>S | No | SGRP | |
| s15-144667 | 155 | N>T | No | SGRP | |
| s15-145050 | 283 | I>V | No | SGRP |
No associated diseases with Q12010
2 regional properties for Q12010
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | PQ-loop repeat | 13 - 70 | IPR006603-1 |
| repeat | PQ-loop repeat | 212 - 270 | IPR006603-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of fungal-type vacuolar membrane | The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| basic amino acid transmembrane transporter activity | Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| basic amino acid transmembrane export from vacuole | The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2T9K0 | TMEM44 | Transmembrane protein 44 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQLVPLELNR | STLSGISGSI | SISCWIIVFV | PQIYENFYRK | SSDGLSLLFV | VLWLAGDVFN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMGAVMQHLL | STMIILAAYY | TVADIILLGQ | CLWYDNEEKP | AVDPIHLSPA | NPINENVLHD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFNEQQPLLN | SQGQPNRIDE | EMAAPSSDGN | AGDDNLREVN | SRNLIKDIFI | VSGVVFVGFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SWYVTYCVNY | TQPPPVEDPS | LPVPELQINW | MAQIFGYLSA | LLYLGSRIPQ | ILLNFKRKSC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGISFLFFLF | ACLGNTTFIF | SVIVISLDWK | YLIMNASWLV | GSIGTLFMDF | VIFSQFFIYK |
| RNKKFILN |