Q12001
Gene name |
ALG6 (YOR002W, UNA544) |
Protein name |
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
Names |
Asparagine-linked glycosylation protein 6, Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR002W |
EC number |
2.4.1.267: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q12001
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6SNH | EM | 390 A | X | 1-544 | PDB |
| 6SNI | EM | 300 A | X | 1-544 | PDB |
| AF-Q12001-F1 | Predicted | AlphaFoldDB |
8 variants for Q12001
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-329426 | 3 | I>M | No | SGRP | |
| s15-329428 | 4 | G>D | No | SGRP | |
| s15-329545 | 43 | F>S | No | SGRP | |
| s15-329562 | 49 | L>V | No | SGRP | |
| s15-330439 | 341 | I>T | No | SGRP | |
| s15-330567 | 384 | I>V | No | SGRP | |
| s15-330813 | 466 | D>N | No | SGRP | |
| s15-330883 | 489 | A>V | No | SGRP |
No associated diseases with Q12001
4 regional properties for Q12001
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aldo/keto reductase, conserved site | 39 - 56 | IPR018170-1 |
| conserved_site | Aldo/keto reductase, conserved site | 145 - 162 | IPR018170-2 |
| conserved_site | Aldo/keto reductase, conserved site | 261 - 276 | IPR018170-3 |
| domain | NADP-dependent oxidoreductase domain | 17 - 289 | IPR023210 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.267 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. |
| hexosyltransferase activity | Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| aerobic respiration | The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. |
| dolichol-linked oligosaccharide biosynthetic process | The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. |
| oligosaccharide-lipid intermediate biosynthetic process | The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40351 | ALG8 | Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAIGKRLLVN | KPAEESFYAS | PMYDFLYPFR | PVGNQWLPEY | IIFVCAVILR | CTIGLGPYSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGSPPLYGDF | EAQRHWMEIT | QHLPLSKWYW | YDLQYWGLDY | PPLTAFHSYL | LGLIGSFFNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SWFALEKSRG | FESPDNGLKT | YMRSTVIISD | ILFYFPAVIY | FTKWLGRYRN | QSPIGQSIAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SAILFQPSLM | LIDHGHFQYN | SVMLGLTAYA | INNLLDEYYA | MAAVCFVLSI | CFKQMALYYA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PIFFAYLLSR | SLLFPKFNIA | RLTVIAFATL | ATFAIIFAPL | YFLGGGLKNI | HQCIHRIFPF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARGIFEDKVA | NFWCVTNVFV | KYKERFTIQQ | LQLYSLIATV | IGFLPAMIMT | LLHPKKHLLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVLIACSMSF | FLFSFQVHEK | TILIPLLPIT | LLYSSTDWNV | LSLVSWINNV | ALFTLWPLLK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KDGLHLQYAV | SFLLSNWLIG | NFSFITPRFL | PKSLTPGPSI | SSINSDYRRR | SLLPYNVVWK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SFIIGTYIAM | GFYHFLDQFV | APPSKYPDLW | VLLNCAVGFI | CFSIFWLWSY | YKIFTSGSKS |
| MKDL |