Q11NV4

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465)
KEGG Pathway
chu:CHU_3676
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q11NV4

Entry ID Method Resolution Chain Position Source
AF-Q11NV4-F1 Predicted AlphaFoldDB

No variants for Q11NV4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q11NV4

No associated diseases with Q11NV4

3 regional properties for Q11NV4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 17 - 695 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 745 - 896 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 697 - 881 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKYNEKKTEL SEVGKEVQQF WNDKKIFEKS VETREGNPTF TFYEGPPSAN GTPGIHHVMG
70 80 90 100 110 120
RTVKDIFCRF KTMQGFQVKR KGGWDTHGLP VELQVEKELG ITKEDIGKKI TVEQYNQKCR
130 140 150 160 170 180
EAVMKYKSQW DELTVKMGYW VDLEKPYITF ENNYIESVWY LLKEFHQKKL LYKGYTIQPY
190 200 210 220 230 240
SPAAGTGLSS HELNQPGTYK DVRDTSAVAQ FKLKANPKFA DNTYFLAWTT TPWTLPSNSA
250 260 270 280 290 300
LAVGENIEYV LVSTFNPYTF KPVQVILAKA LLGKYFSEKA KDLSLEAYKD GDKLIPFKIL
310 320 330 340 350 360
QSYKGKDLVG IEYEQLMPYL QPETPAFRVI AGDFVSTEDG TGIVHIAPTF GADDARVAKL
370 380 390 400 410 420
AGIPSIVTKD DRGNEYPLVD KRGRFTKEVT DFAGEYVKEA YLTDEEKEAE RVKQGRDKYL
430 440 450 460 470 480
SVDERISIKL KEANRAFKVE KYEHSYPHCW RTDKPVLYYP LDSWFIKTTA KKERLVELNK
490 500 510 520 530 540
TINWKPESTG VGRFGNWLEN LVDWNLSRSR YWGTPLPIWR SEDGSEEKCI GSIEELKTEI
550 560 570 580 590 600
AKAQKAGIET ATDIKDLHRP YVDNIVLVSD SGKPMKRELD LIDVWFDSGA MPYAQWHYPF
610 620 630 640 650 660
ENKELFNNNY PADFIAEGVD QTRGWFFTLH AISGMLYDKV AFKNVIANGL VLDKNGNKMS
670 680 690 700 710 720
KRVGNVVNPF ETIDKYGPDA TRWYMITNAP PWDNLKFNLD GITEVQRRFF GTLQNTYSFF
730 740 750 760 770 780
ALYANLDNFT FAEAEIPLAQ RTESDRWILS KLQSLVKDVA DAYSDYEPTK AGRAIQDFVV
790 800 810 820 830 840
DDLSNWYVRL NRKRFWKGEY NADKTAAYQT LYTCLETVAK LGAPIAPFYM DKLFSDLNQV
850 860 870 880 890 900
SKKNAVESVH LADFPKVNEA FLDVELEERM SLAQRISSLV HSIRKAQTIK VRQPLSRILI
910 920 930 940 950 960
PILQPHLKAQ IQAVEDLIKN EVNIKAVEYI EDTSGVVIKT IKPNFKKLGK EYGAKLKEIG
970 980 990 1000 1010 1020
NAIAELRAED ITAIERNVFE LKLADGTVIP ITSEDVEIRS QDIPGWSVAS EGGITVALDI
1030 1040 1050 1060 1070 1080
TLSDDLRKEG IARDVVNRVQ NLRKDMGLEV QDKIRITIQK VDELINSALS ANQEYICTET
1090 1100
QAFSLELVEK LADGKEVEMD EQTLIMKIEK