Q108U6

PR
Gene name
MET
Protein name
Hepatocyte growth factor receptor
Names
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Species
Loxodonta africana (African elephant)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

934-1095 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1222-1249 (Activation loop from InterPro)

Target domain

1079-1346 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q108U6

Entry ID Method Resolution Chain Position Source
AF-Q108U6-F1 Predicted AlphaFoldDB

No variants for Q108U6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q108U6

No associated diseases with Q108U6

No regional properties for Q108U6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q108U6

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

4 GO annotations of biological process

Name Definition
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKAPAVLAPG VLVLLFTLVR KSHGECEEAL AKSKMNVNMK YQLPNFTADT PIQNVVLHEH
70 80 90 100 110 120
HIFLGAINNI YVLNDKDLQK VAEYKTGPVL EHPDCLPCQD CSSKANLSGS VWKDNINMAL
130 140 150 160 170 180
LVDTYYDDQL ITCGSVNRGT CQRHVLPPDN PADIHSKVHC MYSPQADEEP SKCPDCVVSA
190 200 210 220 230 240
LGTKVLLTEK DRFINFFVGN TVNSSYLPDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
250 260 270 280 290 300
EFRDSYPIKY VHAFKHNQFI YFLTVQRETL ESQTFHTRII RFCSVDSGLH SYMEMPLECI
310 320 330 340 350 360
LTEKRRKRSA REEVFNILQA AYVSKPGAYL AKQIGALPDD DILYGVFAQS KLDSAEPMNR
370 380 390 400 410 420
SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRRDEYRTE
430 440 450 460 470 480
FTTALQRVDL FTGQFNQVLL TSISTFIKGN LTIANLGTSE GRFMQVVVSR SGLTTPHVNF
490 500 510 520 530 540
RLDSHAVSPE VILEHPLNQN GYTLVITGKK ITKIPLDGLG CDHFQSCSQC LSAPSFVQCG
550 560 570 580 590 600
WCHNKCARAE ECPNGMWTQE ICLPTIYEVF PTSAPLEGGT TLTVCGWDFG FRRNNKFDLK
610 620 630 640 650 660
KTRVLIGNDS CTLTLSESTT NTLKCTVGPA MNKHFNLSII ISNGRGTARY RTFSYVEPVI
670 680 690 700 710 720
TSISPSYGPK AGGTLVTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSVLEC YTPAQSISTD
730 740 750 760 770 780
FPVKLKIDLA NREAYSFSYQ EDPTVYEIHP NKSFISGGST ITGIGKNLNS VSVPRMVINV
790 800 810 820 830 840
QEAGRNFTVA CQHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSN YFDLIYVHNP
850 860 870 880 890 900
VFKPFKKPVM ISMGNENVLE IKGDYIDPEA VKGEVLKVGN KSCENIHLQS EAVLCTVPND
910 920 930 940 950 960
LLKLNSELNI EWKQAVSSTV LGKVIVQPDQ NFTGLIVGVV SISIILLLLL GLFLWLKKRK
970 980 990 1000 1010 1020
QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
1030 1040 1050 1060 1070 1080
SCRQVQYPLT DMSPILTNGD SDSSIPLLQN NVHIDLSALN PELVQAVQHV VIGPSSLIVH
1090 1100 1110 1120 1130 1140
FNEVIGRGHF GCVYHGTLLD NGDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV
1150 1160 1170 1180 1190 1200
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
1210 1220 1230 1240 1250 1260
FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK
1270 1280 1290 1300 1310 1320
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
1330 1340 1350 1360 1370 1380
WHPKAEMRPS FSELVSRISA IFSTFIGEHY VHVNTTYVNV KCVAPYPSLL SSQDSVDDEV
DT