Q108U0

PR
Gene name
CFTR (ABCC7)
Protein name
Cystic fibrosis transmembrane conductance regulator
Names
CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel
Species
Loxodonta africana (African elephant)
KEGG Pathway
EC number
5.6.1.6: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

625-719 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q108U0

Entry ID Method Resolution Chain Position Source
AF-Q108U0-F1 Predicted AlphaFoldDB

No variants for Q108U0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q108U0

No associated diseases with Q108U0

10 regional properties for Q108U0

Type Name Position InterPro Accession
domain Cadherin-like 34 - 133 IPR002126-1
domain Cadherin-like 155 - 242 IPR002126-2
domain Cadherin-like 242 - 350 IPR002126-3
domain Cadherin-like 351 - 565 IPR002126-4
domain Cadherin-like 581 - 678 IPR002126-5
domain Cadherin, N-terminal 30 - 111 IPR013164
conserved_site Cadherin conserved site 230 - 240 IPR020894-1
conserved_site Cadherin conserved site 443 - 453 IPR020894-2
conserved_site Cadherin conserved site 553 - 563 IPR020894-3
domain Cadherin, C-terminal catenin-binding domain 800 - 933 IPR031904

Functions

Description
EC Number 5.6.1.6 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Nucleus
  • The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane
  • In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia
  • In Sertoli cells, a processed product is detected in the nucleus
  • ER stress induces GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
chloride channel complex An ion channel complex through which chloride ions pass.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

9 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
chloride channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a chloride channel.
chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other.
intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

10 GO annotations of biological process

Name Definition
bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
chloride transmembrane transport The process in which chloride is transported across a membrane.
intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
transepithelial water transport The directed movement of water (H2O) from one side of an epithelium to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKSPLERAS VISKLFFSWP GPILRKGYRQ HLKLSDIYQI PSVDSADNLS EKLEREWDRE
70 80 90 100 110 120
LASKKNPKLI NALRRCFFWR FVFYGILLYL GEVTKAVQPL LLGRIIASYD PDNKVERSIA
130 140 150 160 170 180
IYLAIGLCLL FIVRTLLLHP AIFGLHHMGM QMRIAMFSLI YKKTLKLSSR VLDKISIGQL
190 200 210 220 230 240
VSLLSNNLNK FDEGLALAHF VWIAPLQVTL LMGLIWDLLQ ASAFCGLAFL IIVALGQAGL
250 260 270 280 290 300
GRMMMKYRDK RAGKINERLV ITSEMIENIQ SVKAYCWEEA MEKMIENLRQ IELRLTRKAA
310 320 330 340 350 360
YVRYFNSAAF FFSGFFVVFL SVLPYAMLKG IILRKIFTTI SFCIVLRMAV TRQFPWAVQT
370 380 390 400 410 420
WYDSLGAINK IQDFLQKQEY KTLEYNLTTT DVVMENVTAF WEEGFGELFE KAKQNNNNRE
430 440 450 460 470 480
ISNGDNSLFF SNFSLLGAPV LKDINFKIER GQLLAVAGST GAGKTSLLMM IMGELEPSEG
490 500 510 520 530 540
KIKHSGRISF CSQFSWIMPG TIKENIIFGV SYDEYRYRSV IKACQLEEDI SKFAEKDNIV
550 560 570 580 590 600
LGEGGITLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV LTEKEIFESC VCKLMANKTR
610 620 630 640 650 660
ILVTSKMEHL KKADKILILH EGSSYFYGTF SELQTLRPDF SSELMGYDSF DQFSAERRNS
670 680 690 700 710 720
ILTETLRRFS LEGDTVSWNE TKKQSFKQAG EFGEKRKNSI LNSINSIRKF SVVQKTPLQM
730 740 750 760 770 780
NGIDEDSDEP LERRLSLVPD SEQGEAILPR SNVINTGPTF QRRRRQSVLN LMTRPSINQG
790 800 810 820 830 840
QNIHRRTAAS ARKMSLAPQA NLTEMDIYSR RLSQDSGLEI SEEINEEDLK ECFFDDVENM
850 860 870 880 890 900
PPVTTWNTYL RYVTVHKSLI FVLIWCLVVF LAEVAVSLVV LYLLRTSSLQ DKGNNTTVNA
910 920 930 940 950 960
NSSYGVIVTN TSSYYLLYIY VGIADSLFAL AIFRGLPLVH TLIKVSKTLH HKMLRSILQA
970 980 990 1000 1010 1020
PMSTFNTLKA GRILNRFSKD IAILDDLLPL TMFDFIQLLL IVIGAVVVVS VLQPYIFLAT
1030 1040 1050 1060 1070 1080
VPVIAAFIIL RAYFLHTSQQ LKQLESEARS PIFTHLVTSV KGLWTLRAFG RQPYFETLFH
1090 1100 1110 1120 1130 1140
KALNLHTANW FLYLSTLRWF QMRIEIIFVI FFIAVTFVSI LTTGEGEGTI GIILTLAMNI
1150 1160 1170 1180 1190 1200
MNTLQWAVNS SIDVDSLMRS VSRIFKFIDM PTEESKPAKS VKPPKDGQLS KVMIIENQHV
1210 1220 1230 1240 1250 1260
KKDYNWPSGG HMTVKDLTAK YIDGGNAILE NISFSISPGQ RVGLLGRTGS GKSTLLSAFL
1270 1280 1290 1300 1310 1320
RLLNTEGEIQ IDGVSWDSIT LQQWRKAFGV IPQKVFIFSG TFRKNLDPYE QCSDQEIWKV
1330 1340 1350 1360 1370 1380
ADEVGLRSVI EQFPGKLDFV LVDGGYVLSH GHKQLMCLAR SVLSKAKILL LDEPSAHLDP
1390 1400 1410 1420 1430 1440
ITYQIIRRTL KQAFADCTVI LCEHRVEAML ECQQFLVIEE NTVRQYDSIQ KLLNEKSLFR
1450 1460 1470 1480
QAISPLDRMK LLPHRNSSRH RSRSQIAALK EETEEEVQET RL