Q10712

PR
Gene name
LAPA1 (LAP, LAP2)
Protein name
Leucine aminopeptidase 1, chloroplastic
Names
DR57, Leucyl aminopeptidase 1, LAP 1, Proline aminopeptidase 1, Prolyl aminopeptidase 1
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
sly:544017
EC number
3.4.11.1: Aminopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q10712

Entry ID Method Resolution Chain Position Source
4KSI X-ray 220 A A 54-571 PDB
5D8N X-ray 215 A A/B/C 54-571 PDB
AF-Q10712-F1 Predicted AlphaFoldDB

No variants for Q10712

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10712

No associated diseases with Q10712

2 regional properties for Q10712

Type Name Position InterPro Accession
domain Peptidase M17, leucyl aminopeptidase, C-terminal 258 - 565 IPR000819
domain Peptidase M17, leucyl aminopeptidase, N-terminal 93 - 221 IPR008283

Functions

Description
EC Number 3.4.11.1 Aminopeptidases
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

2 GO annotations of biological process

Name Definition
protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATLRVSSLF ASSSSSLHSN PSVFTKYQSS PKWAFSFPVT PLCSKRSKRI VHCIAGDTLG
70 80 90 100 110 120
LTRPNESDAP KISIGAKDTA VVQWQGDLLA IGATENDMAR DENSKFKNPL LQQLDSELNG
130 140 150 160 170 180
LLSAASSEED FSGKSGQSVN LRFPGGRITL VGLGSSASSP TSYHSLGQAA AAAAKSSQAR
190 200 210 220 230 240
NIAVALASTD GLSAESKINS ASAIATGVVL GSFEDNRFRS ESKKSTLESL DILGLGTGPE
250 260 270 280 290 300
IERKIKYAEH VCAGVILGRE LVNAPANIVT PAVLAEEAKK IASTYSDVIS VNILDAEQCK
310 320 330 340 350 360
ELKMGAYLAV AAAATENPPY FIHLCFKTPT KERKTKLALV GKGLTFDSGG YNLKVGAGSR
370 380 390 400 410 420
IELMKNDMGG AAAVLGAAKA LGEIRPSRVE VHFIVAACEN MISAEGMRPG DIVTASNGKT
430 440 450 460 470 480
IEVNNTDAEG RLTLADALIY ACNQGVEKII DLATLTGAIM VALGPSVAGA FTPNDDLARE
490 500 510 520 530 540
VVEAAEASGE KLWRMPMEES YWESMKSGSG DMINTGPGNG GAITGALFLK QFVDEKVQWL
550 560 570
HLDVAGPVWS DEKKNATGYG VSTLVEWVLR N