Q10452

PR
Gene name
gsk3 (skp1, SPAC1687.15)
Protein name
Protein kinase gsk3
Names
Protein kinase skp1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1687.15
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

175-197 (Activation loop from InterPro)

Target domain

32-316 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10452

Entry ID Method Resolution Chain Position Source
AF-Q10452-F1 Predicted AlphaFoldDB

2 variants for Q10452

Variant ID(s) Position Change Description Diseaes Association Provenance
I_931455_C_T 330 R>C No Jeffares_SNPs
I_931554_T_C 363 S>P No Jeffares_SNPs

No associated diseases with Q10452

4 regional properties for Q10452

Type Name Position InterPro Accession
domain Protein kinase domain 32 - 316 IPR000719
active_site Serine/threonine-protein kinase, active site 153 - 165 IPR008271
binding_site Protein kinase, ATP binding site 38 - 61 IPR017441
domain Glycogen synthase kinase 3, catalytic domain 28 - 319 IPR039192

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

7 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
positive regulation of protein localization to kinetochore Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
SREBP signaling pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNHGTKIPVD PFRIIKETAR DGSTGEVKQL SYTSSKVVGS GSFGVVMQVH LIESDSKAAI
70 80 90 100 110 120
KRVLQDKRFK NRELQIMRIM KHPNIVDLIA YYYTTGDNSD EVYLNLVLEF MPETIYRASR
130 140 150 160 170 180
LYTRQKLSMP MLEVKLYIYQ LLRSLAYIHA SGICHRDIKP QNLLLDPENG ILKLCDFGSA
190 200 210 220 230 240
KILVAGEPNV SYICSRYYRA PELIFGATDY THAIDIWSTG CVMAELMLGH PLFPGESGID
250 260 270 280 290 300
QLVEIIKILG TPSREQIKTM NPNYMEHRFP QIRPQPLSRV FSRSVPLDAL DLLSKMLQYT
310 320 330 340 350 360
PTDRLTAAEA MCHPFFDELR DPNTKLHNSR NPDASPRHLP ELFNFSPFEL SIRPDLNQKL
370 380
IPSHARDALP VKLDDFVPIP IHRARID