Q10407

PR
Gene name
mkh1 (SPAC1F3.02c)
Protein name
MAP kinase kinase kinase mkh1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1F3.02c
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

972-997 (Activation loop from InterPro)

Target domain

825-1094 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10407

Entry ID Method Resolution Chain Position Source
AF-Q10407-F1 Predicted AlphaFoldDB

10 variants for Q10407

Variant ID(s) Position Change Description Diseaes Association Provenance
I_616794_G_C 19 Q>E No Jeffares_SNPs
I_616618_A_T 77 F>L No Jeffares_SNPs
I_616490_T_C 120 K>R No Jeffares_SNPs
I_616487_T_C 121 D>G No Jeffares_SNPs
I_616407_T_C 148 S>G No Jeffares_SNPs
I_616058_A_G 264 V>A No Jeffares_SNPs
I_615444_A_G 469 F>L No Jeffares_SNPs
I_615323_G_A 509 T>I No Jeffares_SNPs
I_614925_G_A 642 P>S No Jeffares_SNPs
I_614651_C_T 733 R>H No Jeffares_SNPs

No associated diseases with Q10407

5 regional properties for Q10407

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 212 - 525 IPR001674
domain GMP synthase, glutamine amidotransferase 10 - 205 IPR004739
domain Glutamine amidotransferase 12 - 199 IPR017926
domain NAD/GMP synthase 223 - 257 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 208 - 400 IPR025777

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
cell wall integrity MAPK cascade A MAPK cascade that contributes to cell wall organization or biogenesis.
fungal-type cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAADIGSQSS GSLEERFEQS LHLQNVDKQD WSLNSVLQFL KLYKFNKEWE DVFIKSRIEM
70 80 90 100 110 120
DLFINLADQS KAEEFAFKNK LSKESAIQLS SCIRKTLLAP SSTRVPSKNS SYETLTYSAK
130 140 150 160 170 180
DSSDDVFTET NSGFRSSNQN SSLKSFQSVP DSNVNVFGGF GGSVVDNNEL LSTGKNSHQT
190 200 210 220 230 240
TSLNLEGSPI NLHAYKGTVT SIINDDSRNI NKKTLSKQPV SEHKEKQTSF LRRFRVPGFS
250 260 270 280 290 300
RDKDKTKDCP SSNSNPFHLA SSNVKTLDAS LDQGEWVPRI HRLESQIGLI SKKKSFVLAT
310 320 330 340 350 360
MDDMKFTVVD ITNVQNATQL RKLIAKSMYL DISIDQFDLF LTEVGGAQYI EILDDRKLDI
370 380 390 400 410 420
ARLYSDEFGT IKFFVKPSQN EESGMDSDTY LSFGTKSSST YKADDDSIYH RKEDFKKQPS
430 440 450 460 470 480
YPVLTSDFEI TDAGPNLSLS GHQPDNKYYK GFSSAPNLAV VPELPSRRFR GFEKIRGAKG
490 500 510 520 530 540
EMATKILDAT EAQSEKNKFT VCRPHKKVTL KMPLNSGSSA PQSPSSNTSA SVLTRNFVAH
550 560 570 580 590 600
RDPPPPPTET SSLRRKNTLT RRPSIRHARS SPYIDTGHNE ASKFSHTSFD PKASSKSSNS
610 620 630 640 650 660
LKESVEALSE IPFEDAPALD ESDLSGDPFW AIQPKQSSSQ VPKENHHNIQ SKLSINTEAA
670 680 690 700 710 720
TDLKANELSS PKTPEYCRGD DRSISLSPLS YRLRKSKHIR ESPPSSKVIN SGNWEVRPSA
730 740 750 760 770 780
DDLYEDVDRF FPRYDLDKVL VVDQSRMVSS PSKVSIRPKM KSVRLLAREA SEARKEIRHN
790 800 810 820 830 840
ARRNKSGNLL RRSSTKLWGS RIVELKPDTT ITSGSVVSQN ATFKWMKGEL IGNGTYGKVF
850 860 870 880 890 900
LAMNINTGEL IAVKQVEIPQ TINGRHDQLR KDIVDSINAE ISMIADLDHL NIVQYLGFEK
910 920 930 940 950 960
TETDISIFLE YVSGGSIGRC LRNYGPFEEQ LVRFVSRQVL YGLSYLHSKG IIHRDLKADN
970 980 990 1000 1010 1020
LLIDFDGVCK ISDFGISKHS DNVYDNDANL SMQGSIFWMA PEVIHNDHQG YSAKVDVWSL
1030 1040 1050 1060 1070 1080
GCVVLEMLAG RRPWSTDEAI QAMFKLGTEK KAPPIPSELV SQVSPEAIQF LNACFTVNAD
1090 1100 1110
VRPTAEELLN HPFMKCDEEF NFKDTNLYDM LCKRKS