Q10366

PR
Gene name
pik1 (SPAC22E12.16c)
Protein name
Phosphatidylinositol 4-kinase pik1
Names
PI4-kinase, PtdIns-4-kinase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22E12.16c
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

150-257 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

727-749 (Activation loop from InterPro)

Target domain

549-851 (Catalytic domain of Type III Phosphoinositide 4-kinase beta)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10366

Entry ID Method Resolution Chain Position Source
AF-Q10366-F1 Predicted AlphaFoldDB

3 variants for Q10366

Variant ID(s) Position Change Description Diseaes Association Provenance
I_5051427_G_A 180 P>S No Jeffares_SNPs
I_5050616_T_C 450 D>G No Jeffares_SNPs
I_5050596_A_C 457 L>V No Jeffares_SNPs

No associated diseases with Q10366

4 regional properties for Q10366

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 558 - 849 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 1 - 123 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 583 - 597 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 694 - 714 IPR018936-2

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Golgi apparatus
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

3 GO annotations of biological process

Name Definition
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSSNSGNEL LLRFFESAHF TSQLCVAYLS RYPNNIGIHH FLCEKLATFP YEEIEFFIPQ
70 80 90 100 110 120
LIHLVLNKDS ESVALEEFII SQCEQNTQCA LITFWYLQAH MVDLGLQPHS SCFKICKRLY
130 140 150 160 170 180
NRIQILVFMS SSSLIQSQQK ISENVTPALI LSGIMLGGVC VPELLKKAGP IAIAQGRKAP
190 200 210 220 230 240
RQDPDESDVD VLRRLSTEPR YSLDVLRSSL NNSIVEQHSE VSLRLKAPEL TRTHSYQSSA
250 260 270 280 290 300
TLSIDEQRRV LRSNYFQQEI QFLFALQDIS IRLIIVPRQA RLSSLRAELA LLNNNLPADV
310 320 330 340 350 360
NIPLLRSYHK EVSHKIVRID PKEATILNSA ERVPYLIMVE VLSGELSFEP QSKKNKAKVQ
370 380 390 400 410 420
KIVSHKNQRK RWFDLTDVDP YTNLQDSTDN DISESESEGG DLSMSPLIKG LVPDTLSLSK
430 440 450 460 470 480
SFSSFGNVSL QVPSSHRDTD VVLLSGRHSD SDGNGALKRS KIYASEITAR MRAAATMLSQ
490 500 510 520 530 540
LDAEGSRRPK AETERIKNSI ILDMQRLEEE RLNEPSIYPV SVDISCAEDL RFGKETQKAE
550 560 570 580 590 600
RKGDRDDPSA ATFQEDWYAK KERIRKSSPY GHYPNWDLVS VIVKTGADLR QETFACQLIY
610 620 630 640 650 660
AFQRVWLECK EKVWVRRMKI LVTGDNSGLI ETITNAISVH SIKKNLTKQL REAELAQGKI
670 680 690 700 710 720
AGKNVVTLKD YFIKQFGDPN SSRYRQAQTN FLQSLVAYSI ISYLLQLKDR HNGNVLIDSE
730 740 750 760 770 780
GHIIHIDFGF LLTNTPGNVG FESAPFKLTA DYLEILDDRF DEYRSLMKAA FKSVRKNADQ
790 800 810 820 830 840
IILLVEVMQN NSTMPCFRAG ENTSAQLLQR FQLQLGDKEC DDFVDLLIQK ANCSVWTRLY
850
DLFQNITNGI Y