Q10337
Gene name |
brc1 (SPBC582.05c) |
Protein name |
BRCT-containing protein 1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC582.05c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q10337
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3L40 | X-ray | 155 A | A/B | 659-877 | PDB |
| 3L41 | X-ray | 145 A | A | 659-878 | PDB |
| AF-Q10337-F1 | Predicted | AlphaFoldDB |
No variants for Q10337
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q10337 | |||||
No associated diseases with Q10337
6 regional properties for Q10337
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BRCT domain | 14 - 104 | IPR001357-1 |
| domain | BRCT domain | 106 - 196 | IPR001357-2 |
| domain | BRCT domain | 218 - 296 | IPR001357-3 |
| domain | BRCT domain | 311 - 399 | IPR001357-4 |
| domain | BRCT domain | 652 - 744 | IPR001357-5 |
| domain | BRCT domain | 767 - 864 | IPR001357-6 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| chromosome, subtelomeric region | A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| rDNA heterochromatin | A region of heterochromatin located at the rDNA repeats in a chromosome. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| postreplication repair | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKIKLLNVK | TPNHYTIIFK | VVAYYSALQP | NQNELRKKEL | FIKNDGKALS | FPYDWKLATH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VICDDFSSPN | VQEGSKRSLR | LAKTNWIRDC | VDKNTLLNYS | FYSCNPYLLF | KGICASSCQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSYQSSLIDD | ALETFGGRFS | KGLMKSMTHL | FTYSGMGAKC | KKVLDKPSLS | IKLIHPQWLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DCLQFGQLID | QDPYLFPNPS | YKKNDSSISK | AEPTSLFRNV | LHGKRIYFSN | DLNLPTNFRH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLQKFSVGIG | AKIAESINDC | DIFIGLKRDT | IEFNLASNKN | TTIGTISWLL | NLFVLGSWKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLLNALHYPF | PSVGFLKDQM | VAVTNYTDAA | RIYLEKLLLA | CGATYTKDLK | PTNTLLIAAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYGQKYGAAK | VWNIPTVHHS | WLYSSFKNLS | SQAFTDFPVP | LDDSYMDFIF | PCPLNVEKGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FEDTLKSSLT | KGNSEVLLDD | LSDPSVSSIK | GNKTNEELEK | EFKSTSDNFG | KHIILTSSFS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQSADKGSSL | AAEDDRNDEG | STITGVNREL | QDEGRLEIDA | KSSKTNTPPS | PLLVGTPSKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLKEASSDDE | LPVLATKLVD | NVIKEKSPLS | LTPKVVVPSH | KETYTDEKKL | IDELDRVNPL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSSQLLRSKR | KSAATALSML | QNVIMPDVLA | FEREKKRRQT | HRSVSSGEVS | RESSESRNTN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKASKRVYIT | FTGYDKKPSI | DNLKKLDMSI | TSNPSKCTHL | IAPRILRTSK | FLCSIPYGPC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVTMDWINSC | LKTHEIVDEE | PYLLNDPEKE | LELGCTLESA | LKRARAQGPS | LLEDYVVYLT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SKTVAPENVP | AVISIVKSNG | GVCSTLNVYN | KRLARHLEDG | NVVLITCNED | SHIWTNFLDN |
| 850 | 860 | 870 | |||
| ASQNKTIFLQ | NYDWLIKTVL | RQEIDVNDRI | ADEFARAV |