Q10334

PR
Gene name
SPBC582.08
Protein name
Putative alanine aminotransferase
Names
Glutamate pyruvate transaminase, GPT, Glutamic--alanine transaminase, Glutamic--pyruvic transaminase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC582.08
EC number
2.6.1.2: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

269-349 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10334

Entry ID Method Resolution Chain Position Source
AF-Q10334-F1 Predicted AlphaFoldDB

No variants for Q10334

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10334

No associated diseases with Q10334

1 regional properties for Q10334

Type Name Position InterPro Accession
domain Aminotransferase, class I/classII 116 - 490 IPR004839

Functions

Description
EC Number 2.6.1.2 Transaminases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
L-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
L-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFTDYPNDIN CESPRMSDLD GFCQNAFSDL NSLNQQVFKA NYAVRGALAI LADEIQDDLL
70 80 90 100 110 120
ENPSSYPFSE IVYANIGNPQ QMGQSPITFV RQVLSLCQYP TLLDHAEEKW FQNLFPTDVV
130 140 150 160 170 180
QRSKMLLKES GSLGAYSASQ GIPLVRRHVA DFIRARDGFD CEPSDIYLTS GASHAARLIM
190 200 210 220 230 240
TLIIARPTDG VMVPAPQYPL YGAQIDLMSG SMVSYSLSEE NNWDIDFDQF KKSFDEASKK
250 260 270 280 290 300
GINVRLCVVI NPGNPTGACI SENSMEKVLR FAKAKGIVLL ADEVYQNNIY QNKFHSFRRK
310 320 330 340 350 360
LGELREKEPD NHWDQVSLIS VNSVSKGQFG ECGQRGGYLD VVNIPEPAKD QILKLATIDI
370 380 390 400 410 420
CPPVAGQLLV DMLVNPPKPG DPSYDLFIKE VDEIHEALRL QCRQLYEGTK RMKRVSCLEP
430 440 450 460 470 480
HGAMYLHPSV SLPEKLITTA KAQKIQPDEF YAIELLKRSG ICVVPGSGFG QPEGDYHIRI
490 500
TFLAKGTEYI ERFVKAHNEI MDLYE