Q10313

PR
Gene name
trl1 (SPAC17G8.01c, SPAC6C3.10c)
Protein name
tRNA ligase 1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC17G8.01c
EC number
6.5.1.3: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

571-643 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10313

Entry ID Method Resolution Chain Position Source
AF-Q10313-F1 Predicted AlphaFoldDB

17 variants for Q10313

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2343667_A_G 15 S>P No Jeffares_SNPs
I_2343187_G_A 175 H>Y No Jeffares_SNPs
I_2342973_C_T 246 S>N No Jeffares_SNPs
I_2342829_T_C 294 Y>C No Jeffares_SNPs
I_2342712_G_A 333 T>I No Jeffares_SNPs
I_2342271_G_A 480 T>I No Jeffares_SNPs
I_2342272_T_A 480 T>S No Jeffares_SNPs
I_2341875_C_T 612 G>D No Jeffares_SNPs
I_2341873_A_T 613 S>T No Jeffares_SNPs
I_2341867_T_C 615 T>A No Jeffares_SNPs
I_2341687_T_C 675 S>G No Jeffares_SNPs
I_2341686_C_T 675 S>N No Jeffares_SNPs
I_2341683_C_T 676 R>Q No Jeffares_SNPs
I_2341648_T_C 688 K>E No Jeffares_SNPs
I_2341414_C_T 766 G>R No Jeffares_SNPs
I_2341396_T_G 772 T>P No Jeffares_SNPs
I_2341381_T_A 777 I>L No Jeffares_SNPs

No associated diseases with Q10313

3 regional properties for Q10313

Type Name Position InterPro Accession
domain tRNA ligase, phosphodiesterase 546 - 785 IPR015965
domain tRNA ligase, kinase domain, fungi 387 - 543 IPR015966
domain T4 RNA ligase 1-like, N-terminal 65 - 300 IPR019039

Functions

Description
EC Number 6.5.1.3 Forming phosphoric ester bonds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

4 GO annotations of molecular function

Name Definition
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA.
RNA ligase (ATP) activity Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).

1 GO annotations of biological process

Name Definition
tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRDQRVCIF GEKKSTVRSV TFKAPKSNYD LTSWRIWEQA FRLNVSNSKK CFDTISGHRI
70 80 90 100 110 120
TLPTNARGLF TGYDYESKRH RIVIRGYDKF FNIDEVPITT WDALSQHTKG PYELTVKENG
130 140 150 160 170 180
CIIFIAALPD GQIIVSSKHS LGIVEGQSVS HANVGERWLE KHLQSVGRTK QELAHELLRR
190 200 210 220 230 240
DMTAVAELCD DEFEEHILPY TGNSRGLYLH GLNRNCPQFI TASSCEVAEF AEQWGFMKVS
250 260 270 280 290 300
SFFMDSIHEL KAFLENASKD GKWNNRAIEG FVIRCHSDHS SLEQQSSNDF FFKYKFPEPY
310 320 330 340 350 360
GMFRQWREVT KMLISGKKPS YTKYKKVTAE YITFCDKKFK EDEDAKRLYM SNKGIISLRD
370 380 390 400 410 420
EFLVLSKLDL MHLSVSNDND CGKEFTLLVP IATIGCGKTT VAKILEKLFG WPVVQNDNLP
430 440 450 460 470 480
SGKGGPKRFA KAIIEEFRNG HSVVFADRNN HISNMRSTLQ TDILALIDGV RFVALPFKHT
490 500 510 520 530 540
PEVPEFVQNR VLQRGDRHQS IKVSEGVDKV KAIMNTFYKQ YKPFDPAGNK HDANYDDIIE
550 560 570 580 590 600
LDPLIGSLEN ARRIVNYFKK NIPELIPNDP SDDDYAAALN YAVNEYVPTY RKTFGNDSKK
610 620 630 640 650 660
IKNKITAEGI TGSSTCFKKA PRYFGVLLDR KTVESSLVQV LTIANLQWQE AFSRYTLQDS
670 680 690 700 710 720
FHITMIHESQ KPVNSRIWEQ YLQHMHDKNT TKMGNISFRI THLVWDDRVI CFRVTMNENS
730 740 750 760 770 780
VWYGKTCNPQ LHITLGTSSS DVKAFESNFL LKKLRWQGDE VDSTDGNVRY LTVLPKIIIE
GMLEPVY