Q10306

PR
Gene name
cit1 (SPAC6C3.04)
Protein name
Probable citrate synthase, mitochondrial
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6C3.04
EC number
2.3.3.16: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10306

Entry ID Method Resolution Chain Position Source
AF-Q10306-F1 Predicted AlphaFoldDB

2 variants for Q10306

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2328838_C_A 65 A>E No Jeffares_SNPs
I_2329746_G_A 368 V>I No Jeffares_SNPs

No associated diseases with Q10306

1 regional properties for Q10306

Type Name Position InterPro Accession
active_site Citrate synthase active site 363 - 375 IPR019810

Functions

Description
EC Number 2.3.3.16 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.

3 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMIILNAPRF MTNTRLASTR RLASSLLSQA SLRSRQLNPL FTSSYSTRSS SLKDRLAELI
70 80 90 100 110 120
PEKQAEIKKF RAEHGQDVIG EVTINQMYGG ARGVRSLIWE GSVLDPNEGI RFRGYTIPEC
130 140 150 160 170 180
QKLLPSSPNG KQPLPESLFW LLVTGEIPTL SQVQALSADW AARSQLPKFV EELIDRCPPT
190 200 210 220 230 240
LHPMAQFSLA VTALEHDSAF AKAYERGMNK HDYWKYEYED CMDLIAKTVP IAGRIYRNLY
250 260 270 280 290 300
RDGVVAPIQM DKDHSYNFAN VLGFANNEEF VELMRLYLTI HADHEGGNVS AHTGHLVGSA
310 320 330 340 350 360
LSSPFLSMAA SLNGLAGPLH GLANQEVLNF LITMKKEIGD DLSEETIKSY LWKLLNSGRV
370 380 390 400 410 420
VPGYGHAVLR KTDPRYTAQR EFALEHLPKD PMFQLVSRLY EIVPGVLTEH GKTKNPYPNV
430 440 450 460 470 480
DSHSGVLLQY YGLKEQSFYT VLFGVSRTLG VASQLIWDRA LGLPIERPKS FSTEALKKMV
ETK