Q10297

PR
Gene name
kap114 (SPAC22H10.03c)
Protein name
Importin subunit beta-5
Names
114 kDa karyopherin, Karyopherin subunit beta-5, Karyopherin-114
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22H10.03c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10297

Entry ID Method Resolution Chain Position Source
AF-Q10297-F1 Predicted AlphaFoldDB

12 variants for Q10297

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2375609_G_A 241 L>F No Jeffares_SNPs
I_2375566_T_C 255 Y>C No Jeffares_SNPs
I_2375300_C_T 344 V>I No Jeffares_SNPs
I_2375285_G_A 349 P>S No Jeffares_SNPs
I_2375223_A_T,G 369 H>Q No Jeffares_SNPs
I_2375146_A_G 395 V>A No Jeffares_SNPs
I_2374913_C_T 473 D>N No Jeffares_SNPs
I_2374464_C_T 622 M>I No Jeffares_SNPs
I_2374415_G_A 639 P>S No Jeffares_SNPs
I_2374265_A_T 689 S>T No Jeffares_SNPs
I_2373455_C_T 916 D>N No Jeffares_SNPs
I_2373341_C_T 942 V>I No Jeffares_SNPs

No associated diseases with Q10297

1 regional properties for Q10297

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 24 - 100 IPR001494

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

1 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVESKIIKLL EQVQSADPNS RIQAELGLRD LEKYHDFAAK LTDIASSGAS VPLRQGSLIY
70 80 90 100 110 120
LQRYIVHHWS PLFEQFQDGP IPDENVKKHV RETLLHLLVS LDNFTLIKAV AYAVSLIANV
130 140 150 160 170 180
DYPDEWPEVV PAVLHLLQST NENSINASLD VLDELVDESL VEEQFFIIAP QLASILYQFI
190 200 210 220 230 240
FSAPPNDSMR MLQARGIKLF RSCLELIEIY KETKAEHVRV FLEQILPPWM DMFSHKFEVS
250 260 270 280 290 300
LVDDRQVILP DSCGYFCIMG EIAMTLTKLR ELFPSKLTPY VVTFVELVWN IIEKLLDPYI
310 320 330 340 350 360
REVVFSDGLD DSAFGDKYPI RYLVELLLFV SVALQSKFVQ NLFVSNTVPV PPLPPCIPLL
370 380 390 400 410 420
VQYTQLPKHQ IEVYESDVSE YIANEFSMDF ASDTVRGAAI SVLSAFEEHT TLPIQQSLRE
430 440 450 460 470 480
MSATYILNNE INWIYQEALL YACCSVDAAS DDTYDDYLDP IYEAIKVRID YSDAPILLLS
490 500 510 520 530 540
RFFLFIGYFS ESTVVASQFF QIIMNNLVNA LQVDTVQYAA MKAIERFCSV GKVKPILSLQ
550 560 570 580 590 600
PMILEVLSQY ASKSSDEALV LLVEAISSAV KLDCAKAAEL GNSVIPLLFN LVATNASDPY
610 620 630 640 650 660
ICGIIEDTFE DIIHAANNYE SMCEITLPEL LQVLNQEDPI MVNIGATLLS CLIRAGPSPL
670 680 690 700 710 720
PNGFVGYVLP PVYKITQIHS GDTELLQLSQ EILKGLLEKD TPQLLETEIS GSSGFQYILF
730 740 750 760 770 780
ILHQLLDKES DDSACFLVGP ILLELADHAS QMVDLQSILL SCIKRLAIAE QPRFIQSIIY
790 800 810 820 830 840
VFAKLIVKDS LGMMHFLTSS LLNEQGLTAF EVLMTVWCDN FVYFSNFKNI SIICIAMTKI
850 860 870 880 890 900
YSFDSPLLDS VQVKGELISH SNRIITRSQS KLHPEEYSYV SVGEKILRLL SEEFVSLSKD
910 920 930 940 950 960
AIVEEVSDDG ADDWDDGPIS AETFGLSAND VNELSKDEFS GVDNSEDEDN TDLQFYLLEF
970 980 990
FKEAMKSNLH NINEVVFRLP QEEQDALVQI KEK