Q10292

PR
Gene name
mek1 (SPAC14C4.03)
Protein name
Meiosis-specific serine/threonine-protein kinase mek1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC14C4.03
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

302-324 (Activation loop from InterPro)

Target domain

160-421 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10292

Entry ID Method Resolution Chain Position Source
AF-Q10292-F1 Predicted AlphaFoldDB

6 variants for Q10292

Variant ID(s) Position Change Description Diseaes Association Provenance
I_5231219_G_A 27 S>N No Jeffares_SNPs
I_5231464_G_A 95 M>I No Jeffares_SNPs
I_5231712_T_C 178 M>T No Jeffares_SNPs
I_5232235_G_A 336 R>K No Jeffares_SNPs
I_5232342_G_A 372 A>T No Jeffares_SNPs
I_5232508_G_A 427 R>H No Jeffares_SNPs

No associated diseases with Q10292

4 regional properties for Q10292

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 61 - 131 IPR000253
domain Protein kinase domain 160 - 421 IPR000719
active_site Serine/threonine-protein kinase, active site 277 - 289 IPR008271
binding_site Protein kinase, ATP binding site 166 - 189 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
linear element A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
meiotic recombination checkpoint signaling A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
positive regulation of initiation of premeiotic DNA replication Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication.
positive regulation of reciprocal meiotic recombination Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
protein phosphorylation The process of introducing a phosphate group on to a protein.
reciprocal meiotic recombination The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFLSHAMLS RSESTQILCE LSQIDESTMD PQYTEDDVLA RLFVFSSSSP QTVLNVKKYE
70 80 90 100 110 120
DVSVGRSNTC NYQLLQFTAS YKHFRVYSVL IDDDMDPLVY CEDQSSNGTF LNHRLIGKGN
130 140 150 160 170 180
SVLLSDGDIL DVRHCASFLF QQKYTTDNDF HHEYAGERFN ITQRLLGIGG FSRIYMAMDN
190 200 210 220 230 240
NTGGQYACKI IDKKKISTKR FFEDHEMTIL RKLDHPNIIK VNMEYNSETQ FFIFEEMVTG
250 260 270 280 290 300
GDLFSYLTKL GTVPEVTTLF IMFQILQGLK YLHEQNIIHR DLKLENILIA SSSDTIFRII
310 320 330 340 350 360
LTDFGVARCM QKGKRLSTFV GTPEYTAPEI QRLKGRSQVE KENSSGYGKE VDLWSLGVIM
370 380 390 400 410 420
FLLLSGNSPS FADGVKEKQV DFRDPVWKSV SRQAKDLISN LLKTNPPDRF TVKQCLSHPW
430 440
FARHSSRLTK LYETRILKPL KHSRL