Q10290
Gene name |
mal2 (SPAC25B8.14) |
Protein name |
Inner kinetochore subunit mal2 |
Names |
CENP-O homolog, Constitutive centromere-associated network protein mal2, Sim4 complex subunit mal2 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC25B8.14 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10290
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10290-F1 | Predicted | AlphaFoldDB |
7 variants for Q10290
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_4185581_G_A | 20 | R>K | No | Jeffares_SNPs | |
| I_4185931_G_A | 137 | G>S | No | Jeffares_SNPs | |
| I_4186157_C_T | 212 | A>V | No | Jeffares_SNPs | |
| I_4186182_G_C | 220 | L>F | No | Jeffares_SNPs | |
| I_4186360_T_A | 280 | L>I | No | Jeffares_SNPs | |
| I_4186375_C_T | 285 | R>C | No | Jeffares_SNPs | |
| I_4186408_G_A | 296 | A>T | No | Jeffares_SNPs |
No associated diseases with Q10290
No regional properties for Q10290
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q10290 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| condensed chromosome, centromeric region | The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| Mis6-Sim4 complex | A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| centromere complex assembly | The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDDEEGNATL | IDEISVLEAR | RDVLLDELKS | LDNATLSDLV | QKPELSKNLS | VNNEFLKETP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNQPALHYDR | LSGISFFQPN | DPEELSRKTL | LVKNKKTGAI | ETAPSIPLLG | VRFDIMLNPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NIGFTNLSEN | PISSASGMDE | ELEGGNRFDV | PYYIIFRVFH | DSFALYKYTI | PSFLNIQEWA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEYLTGKNPE | RFRIFLWKVD | KLLTAYICRK | NALLQINKSL | TIDGTNISAN | LSCTHLVIQI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKVIQATLVC | SSESTRVVKS | RIYQYSDENW | KRDHRLELSL | LDNKRWVNIL | VSHLTAPESH |
| ASL |