Q10286
Gene name |
itr1 (SPAC4F8.15, SPAC7D4.01) |
Protein name |
Myo-inositol transporter 1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC4F8.15 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10286
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10286-F1 | Predicted | AlphaFoldDB |
7 variants for Q10286
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_2640853_C_T | 192 | W>* | No | Jeffares_SNPs | |
| I_2640771_T_C | 220 | I>V | No | Jeffares_SNPs | |
| I_2640686_C_G | 248 | W>S | No | Jeffares_SNPs | |
| I_2640462_C_T | 323 | V>M | No | Jeffares_SNPs | |
| I_2640333_C_G | 366 | E>Q | No | Jeffares_SNPs | |
| I_2640317_T_A | 371 | N>I | No | Jeffares_SNPs | |
| I_2639708_T_A | 574 | N>I | No | Jeffares_SNPs |
No associated diseases with Q10286
3 regional properties for Q10286
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Sugar transporter, conserved site | 147 - 164 | IPR005829-1 |
| conserved_site | Sugar transporter, conserved site | 391 - 407 | IPR005829-2 |
| domain | Major facilitator superfamily domain | 90 - 533 | IPR020846 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| myo-inositol:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| myo-inositol import across plasma membrane | The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSISSKDFQN | VTSAGFADDT | FAADTFAADK | KSPFESSVFE | NKTQVLPVDS | VSRLSNGARS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSNSNISLSE | PHALNDTVED | QPVSKWVWVL | AFAAGIGGLL | FGYDTGVISG | ALVVIGTSLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GHELTNGGKE | FITSATSLGA | LLGGIIAGAL | ADFFGRKPVI | AIASIIIIVG | SIVQVTAHHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WHMIVGRFVI | GWGVGIASLI | IPLYLSEIAP | SKIRGRLVII | YVLLITAGQV | IAYGIDTAFE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HVHNGWRWMV | GLAMVPAAFQ | LFILIWLPES | PRLLVKKERS | QEAYNTLARI | YPTAHPYEIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKLYLIQEGV | RDPFSGSRWQ | KIVKTFKELY | FNPSNFRALI | LACGLQAMQQ | LSGFNSLMYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSTIFEVVGF | NNPTATGLII | AATNFVFTIV | AFGVIDFFGR | RILLLLTVWG | MIAALIVCAV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AFHFLPKDEN | GNYTSGQSNA | WAIVVLISMI | VYVASYASGL | GNLPWQQSEL | FPMSVRGLGT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GMSTAVNWAG | NLGIGASFLT | LMSEITPTGT | FALYGGLCFL | GWLGALFCYP | DLTDYTIEEI |
| 550 | 560 | 570 | |||
| GELLKHGFGV | RESMRHLKRV | RQERAWSRED | KEQNN |