Q10276

PR
Gene name
SPAC13G7.12c
Protein name
Choline kinase
Names
ATP:choline phosphotransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC13G7.12c
EC number
2.7.1.32: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10276

Entry ID Method Resolution Chain Position Source
AF-Q10276-F1 Predicted AlphaFoldDB

4 variants for Q10276

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2317725_T_C 38 H>R No Jeffares_SNPs
I_2317417_T_C 141 T>A No Jeffares_SNPs
I_2317335_A_G 168 L>P No Jeffares_SNPs
I_2316517_C_T 441 A>T No Jeffares_SNPs

No associated diseases with Q10276

1 regional properties for Q10276

Type Name Position InterPro Accession
domain Choline kinase, N-terminal 11 - 61 IPR007521

Functions

Description
EC Number 2.7.1.32 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
choline kinase activity Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

3 GO annotations of biological process

Name Definition
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVNFASEVDK NNAFDSAHPS RKCKGSLDCN DPDPIFRHKV LVIIHKLAIS SWNRIPLTLC
70 80 90 100 110 120
NKLHIKRISG ALTNAVYYVA PPEGYHAPKL LLRIYGPHVE LFINRQVELE NLKRLARHNI
130 140 150 160 170 180
GPYLIGEFSN GRFEQYMEST TLTCKTIRDP KLSIYVGRRL CELHNFILLH PHEVLEMPAA
190 200 210 220 230 240
WKNCLVWLPK AKAKILGRKH SLAITSEFMK TLEEDFNAYY NWFVEWSRDK KDWFGLKMVF
250 260 270 280 290 300
SHNDTQYGNL LKIKAKKRSI PLSQKHRTLV PVDFEYAGPN LCAFDLANYF AEWMADYHHP
310 320 330 340 350 360
THNYLMDRSR YPDFNARKLV YHAYVEQSAV INDLLEIEDA SLLKTDISDE LKNTFEKQIM
370 380 390 400 410 420
NLEESVRAIS PAANIGWALW GILQCLEEDD EWEDLSVSSQ VADRPEKQLV EGSTVPPIGT
430 440 450
SSFDYIGYSS EKFDLFYEGC AALGLNGRNR STFSYA