Q10269
Gene name |
are1 (SPAC13G7.05) |
Protein name |
Probable sterol O-acyltransferase 1 |
Names |
Sterol-ester synthase 1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC13G7.05 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10269
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10269-F1 | Predicted | AlphaFoldDB |
5 variants for Q10269
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_2306098_A_G | 252 | T>A | No | Jeffares_SNPs | |
| I_2306260_A_G | 306 | N>D | No | Jeffares_SNPs | |
| I_2306345_A_G | 334 | H>R | No | Jeffares_SNPs | |
| I_2306350_A_T | 336 | M>L | No | Jeffares_SNPs | |
| I_2306854_C_G | 504 | Q>E | No | Jeffares_SNPs |
No associated diseases with Q10269
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cortical endoplasmic reticulum | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perinuclear endoplasmic reticulum | The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ergosterol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester. |
| O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ergosterol biosynthetic process | The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. |
| ergosterol metabolic process | The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. |
| lipid droplet formation | A process that results in the assembly, arrangement of constituent parts of a lipid droplet. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDTPRILIT | PSPLSDISTT | INKPNVHPSM | SLLKALPECR | LVVKSKGDKN | NANVVEFPLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RHKQLLIAGK | VYHDYKFKPR | KSIFDRVTDP | NYFAKSEFRG | FYVLFWLSMA | AWVLQLYARS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YWQRDTLLGL | PLARQVFRQF | FVLFSSDFLM | ICLSFFSYGL | QVCIEKNMIR | WANLGYTIQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWQGFYMVLA | VYWVKHRDFP | IVQCVFFTLH | CAVLIMKQFS | YSHHMGYISE | IRILHNEYEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLKFVRECLN | STEKDEKYTF | ELTFPNKPAE | TISTLQAEEI | VALTAKYLSR | QMRSEVGNVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YPDNINFFNY | VDYLLVPSLV | YSMEFPRVAH | FRWHYMAFKA | GSTFGLLALT | LALVDWYFVP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAVAVKDLDF | IGKLRIAPLL | MNKIMFPAII | LYLIMFYLIF | DCILNAFAEI | TKFADRGFYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AWWNTVTWDE | FSREWNKPVH | VFLMRHVYHS | SISGFKLKKS | HAVLLTFLIS | ALVHEFVMLL |
| 490 | 500 | 510 | 520 | 530 | |
| ATGKFRCYIL | TFQLLQIPLY | DLQQMFAFKK | RDILGNVFFW | IGMFTGPSFL | CILYIVF |