Q10267

PR
Gene name
upf3 (SPAC13G7.03)
Protein name
Nonsense-mediated mRNA decay protein 3
Names
Up-frameshift suppressor 3
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC13G7.03
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-278 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10267

Entry ID Method Resolution Chain Position Source
AF-Q10267-F1 Predicted AlphaFoldDB

7 variants for Q10267

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2299124_C_T 49 A>V No Jeffares_SNPs
I_2299132_G_A 52 G>S No Jeffares_SNPs
I_2299593_C_T 169 S>L No Jeffares_SNPs
I_2299701_C_T 205 S>F No Jeffares_SNPs
I_2299791_C_A 235 T>N No Jeffares_SNPs
I_2299856_A_T 257 K>* No Jeffares_SNPs
I_2299907_A_C 274 T>P No Jeffares_SNPs

No associated diseases with Q10267

1 regional properties for Q10267

Type Name Position InterPro Accession
domain UPF3 domain 12 - 160 IPR005120

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

3 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPDISKKRL PCKVLVFNLP PTLPEQVFLQ SINSFLPHVE WHRFSKGKAT VGTRSELLSF
70 80 90 100 110 120
AYLKFQSATA VQEFFRVYQG HTFIDKKNNT YRAIVTIAPY QKIPPSKVKA DSLEGSLEQD
130 140 150 160 170 180
PKFQEFKVQR ESYSQTASND DVIEKLQTST PLLQYLAEKK NAVVEKGKSK PSKKSVKAKK
190 200 210 220 230 240
KLRLAEKPAS NNSKAGKSSQ ESKKSSKAPA ESAAAVIKED KVSDRKKSKK KPKKTPVSNS
250 260 270
TASQASENAS DKKTKEKKSS GKQKIASKKK DQLTTDNV