Q10247

PR
Gene name
SPAC4G9.19
Protein name
Uncharacterized J domain-containing protein C4G9.19
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC4G9.19
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-270 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10247

Entry ID Method Resolution Chain Position Source
AF-Q10247-F1 Predicted AlphaFoldDB

8 variants for Q10247

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2287381_C_T 2 S>L No Jeffares_SNPs
I_2287695_G_A 107 D>N No Jeffares_SNPs
I_2287710_C_T 112 H>Y No Jeffares_SNPs
I_2287731_C_A 119 P>T No Jeffares_SNPs
I_2288106_A_G 244 I>V No Jeffares_SNPs
I_2288125_C_T 250 P>L No Jeffares_SNPs
I_2288171_G_A 265 M>I No Jeffares_SNPs
I_2288172_C_T 266 P>S No Jeffares_SNPs

No associated diseases with Q10247

No regional properties for Q10247

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q10247

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.

1 GO annotations of biological process

Name Definition
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKIFFRLNL VRNSLWRRAA SFTSYSELKS LTPYEILELP RTCTANDIKR KYIELVKKHH
70 80 90 100 110 120
PDKMKNASQL APTESPPEIN KHNEEYFRLL LAANALLSDK RRREEYDRFG IHWNQPSHPT
130 140 150 160 170 180
HPSPQNWSQA RYPTYSRSRR SAGMGSWEEY YYNSYDYMND QNASNKNRKF DDEGMLVFAG
190 200 210 220 230 240
ILSILVIINI YSNYRNGKFY REARSAAIGR AEDNFDYYST GMADLSKDDR ISRFLILREQ
250 260
SKQIPTQQKP SSLPPPERAL PAPTMPTPSS