Q10225

PR
Gene name
btb3 (SPAC13D6.04c)
Protein name
BTB/POZ domain-containing protein 3
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC13D6.04c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10225

Entry ID Method Resolution Chain Position Source
AF-Q10225-F1 Predicted AlphaFoldDB

8 variants for Q10225

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2253071_A_T 40 L>Q No Jeffares_SNPs
I_2253030_G_A 54 L>F No Jeffares_SNPs
I_2252468_T_C 202 S>G No Jeffares_SNPs
I_2252317_G_A 252 A>V No Jeffares_SNPs
I_2252183_T_A 297 N>Y No Jeffares_SNPs
I_2252171_C_T 301 D>N No Jeffares_SNPs
I_2251739_C_T 445 D>N No Jeffares_SNPs
I_2251592_C_T 494 V>I No Jeffares_SNPs

No associated diseases with Q10225

3 regional properties for Q10225

Type Name Position InterPro Accession
domain BTB/POZ domain 165 - 262 IPR000210-1
domain BTB/POZ domain 296 - 403 IPR000210-2
repeat Ankyrin repeat 51 - 136 IPR002110

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASQDQNTGT THVELQGGEN SKKLFSKYDL WSKAMDEKKL SSSLFTVNDT QEFLELCEAC
70 80 90 100 110 120
RRGDLEVVKS LVENYNTPIN QVDQFDYSPL VLASLCGHEP VVKFLLENGA LCERDTFQGE
130 140 150 160 170 180
RCLYGALNDN IRRMLLSYDI TKAIDESQPY ASHITSLLSN SALHFTTDIV FAGQYGRVFA
190 200 210 220 230 240
HKFYLAARSS YFKSKFSKLG PSEHEIEVKH FAKEFESILR YLYLDTNAVF TKQYNNALLS
250 260 270 280 290 300
IGKKFQLNDF IALYEKDREQ LHSRDWKKIQ LAKTQNDLGE FLDYIISNYK VPIESLNQPS
310 320 330 340 350 360
DQYSFHDAYL QSYTHRYPVH RAIMCRCEYF LDMLAGPFLE SNQELPVLSL PFSSSVVEIV
370 380 390 400 410 420
LKFLYTDKTD IAPELALDVV YVADMLSLDK DRSLKSLASI VITKQEEPID SIYDILRTAW
430 440 450 460 470 480
DTSTPRLEQY ASEYMANHLE HLIDDPEFCE LVKESADRIL QRQETDTIEL IDDIRYFLSK
490 500 510 520
RFGIYHEDLC IDGVVDTLTP YESEYNQKME MIDDLLDKLE LQA