Q10205
PR
Gene name |
rrp43 (SPBC17D1.03c) |
Protein name |
Exosome complex component rrp43 |
Names |
Ribosomal RNA-processing protein 43 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC17D1.03c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10205
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10205-F1 | Predicted | AlphaFoldDB |
No variants for Q10205
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q10205 | |||||
No associated diseases with Q10205
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nuclear exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic catabolism of deadenylated mRNA | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. |
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| nonfunctional rRNA decay | An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system. |
| nuclear mRNA surveillance | A process that identifies and degrades defective or aberrant mRNAs within the nucleus. |
| nuclear polyadenylation-dependent mRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. |
| nuclear polyadenylation-dependent rRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. |
| nuclear polyadenylation-dependent tRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. |
| nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay | The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. |
| nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' | The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. |
| nuclear-transcribed mRNA catabolic process, non-stop decay | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon. |
| rRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. |
| U1 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U1 snRNA molecule. |
| U4 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U4 snRNA molecule. |
| U5 snRNA 3'-end processing | Any process involved in forming the mature 3' end of a U5 snRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKTVSGVKQL | SFTPSIFKKI | TPEQYLSHLL | NQDVRSDGRS | VSEFREIVIN | DNCISTANGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIIRAGENVF | VCGIKAEIAE | PFENSPNEGW | IVPNLELSPL | CSSKFKPGPP | SDLAQVVSQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHQTLQQSNL | INLQSLCIFE | KKAAWVLYAD | IICLNYDGSA | FDYAWAALFA | ALKTVKLPTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VWDEDLERVI | CASTLTRPVQ | LSTEVRSFSW | SVFDDKLLAD | PTDEEEDLST | EFLTIMLNSS |
| 250 | 260 | ||||
| KNIVKIIKLG | GTHIQPLLLK | KCIEVARSKF |