Q10186

PR
Gene name
SPAC3F10.12c
Protein name
Uncharacterized bHLH domain-containing protein C3F10.12c
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3F10.12c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10186

Entry ID Method Resolution Chain Position Source
AF-Q10186-F1 Predicted AlphaFoldDB

3 variants for Q10186

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2842903_A_T 7 I>K No Jeffares_SNPs
I_2842717_G_A 69 S>F No Jeffares_SNPs
I_2842718_A_G 69 S>P No Jeffares_SNPs

No associated diseases with Q10186

2 regional properties for Q10186

Type Name Position InterPro Accession
domain Myc-type, basic helix-loop-helix (bHLH) domain 88 - 142 IPR011598
domain Centromere-binding protein 1-like, bHLHzip domain 83 - 169 IPR047206

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRDMSINHL LPPLSGPGQV EQLTGFTNDI VYNDFYAHAV SYNPYPSEKI DFPKKNTAHK
70 80 90 100 110 120
NSTTSTVASS GNTTMEKPCV GSEEWYKAKR LSHKEVERRR REAISEGIKE LANIVPGCEK
130 140 150 160 170 180
NKGSILQRTA QYIRSLKEME EMCREKSNLE KLVADHTIQE LARENARLKS ECERAWRSVE
190 200
LWKQAARSFD SELDVEENSE S