Q10179

PR
Gene name
grs1 (SPAC3F10.03)
Protein name
Putative glycine--tRNA ligase
Names
Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase, GlyRS
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3F10.03
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

93-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10179

Entry ID Method Resolution Chain Position Source
AF-Q10179-F1 Predicted AlphaFoldDB

6 variants for Q10179

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2821784_G_C 100 G>A No Jeffares_SNPs
I_2821969_G_C 162 E>Q No Jeffares_SNPs
I_2822069_A_G 195 E>G No Jeffares_SNPs
I_2822816_C_T 444 S>L No Jeffares_SNPs
I_2822821_C_T 446 P>S No Jeffares_SNPs
I_2823173_A_G 563 N>S No Jeffares_SNPs

No associated diseases with Q10179

3 regional properties for Q10179

Type Name Position InterPro Accession
domain Anticodon-binding 538 - 628 IPR004154
domain Aminoacyl-tRNA synthetase, class II 184 - 520 IPR006195
domain Glycyl-tRNA synthetase-like core domain 15 - 393 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

4 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.
mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEVSKAAAF DRTQFEELMK KRFFFSPSFQ IYGGISGLYD YGPPGSALQS NLVDIWRKHF
70 80 90 100 110 120
VIEESMLEVD CSMLTPHEVL KTSGHVDKFA DWMCKDPATG EIFRADHLVE EVLEARLKGD
130 140 150 160 170 180
KEARGQNSND QPEESDDKKK RKKKVKEIRA TRLDDKTVEE YEFILAQIDN YDGDQLGELM
190 200 210 220 230 240
KKYDIRNPAT NGELETPRQF NLMFETQIGP SGGLKGYLRP ETAQGQFLNF SRLLEFNNGK
250 260 270 280 290 300
VPFASAMVGK AFRNEISPRS GLLRVREFLM AEVEHFVDPK NKEHDRFDEV SHMPLRLLPR
310 320 330 340 350 360
GVQLEGKTDI LEMPIGDAVK KGIVDNTTLG YFMARISLFL EKIGIDMNRV RFRQHMSNEM
370 380 390 400 410 420
AHYACDCWDA EIQCSYGWIE CVGCADRSAY DLSVHSKATK TPLVVQEALP EPVVVEQFEV
430 440 450 460 470 480
EVNRKKFGPR FKRDAKAVEE AMISWPESEK VEKSAQLVAE GKIIVNVNGV EHTVESDLVT
490 500 510 520 530 540
IEKRKHTEHI RTYTPNVIEP SFGLGRILYV LMEHAYWTRP EDVNRGVLSF PASIAPIKAL
550 560 570 580 590 600
IVPLSRNAEF APFVKKLSAK LRNLGISNKI DDSNANIGRR YARNDELGTP FGLTVDFETL
610 620 630 640 650
QNETITLRER DSTKQVRGSQ DEVIAALVSM VEGKSSFEDA LAKFGEFKST QE