Q10178

PR
Gene name
prp10 (sap155, SPAC27F1.09c)
Protein name
U2 snRNP component prp10
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC27F1.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-386 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10178

Entry ID Method Resolution Chain Position Source
AF-Q10178-F1 Predicted AlphaFoldDB

No variants for Q10178

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10178

No associated diseases with Q10178

1 regional properties for Q10178

Type Name Position InterPro Accession
domain Splicing factor 3B subunit 1 229 - 332 IPR015016

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTGTYPYKM FKMDVTNLNK VEDVEIERLR AERELLRRQK EAAKNSSTNG SVNIEGTQDS
70 80 90 100 110 120
NDLQYNAHLF KSSNPKEEYD SAIDVRNDIS QDEDDYKRTN DVNDSYRLVR QYEAPKELLN
130 140 150 160 170 180
EYADESYDPM QERQSKKQIQ DRESDYQKQR YDRQLTPTRV DAFQPDGTQS NGRSYAEVMR
190 200 210 220 230 240
QVELEKEERR VHMELNQRRR EGTLKEVEEE ESISDKKREL ELNNTEISQK PKRSRWDQAP
250 260 270 280 290 300
PSVTQVSTTK RRSRWDKAPE NFTISEHVIE NGISEDLINK EVNVVEEKLR PPVRLLTEEE
310 320 330 340 350 360
LNELLPSEGY AILEPPPGYL ESIHPELLQK GTTLDTYHVP QEQELPLEKE LPAALPTEIP
370 380 390 400 410 420
GVGDLAFFKQ EDVKYFGKLL KVEDEAKLTI AELRERKILR LLLKVKNGTP PMRKSALRQL
430 440 450 460 470 480
TDQARDFGAA ALFNQILPLL MERTLEDQER HLLVKVIDRI LYKLDDLVRP FTHKILVVIE
490 500 510 520 530 540
PLLIDEDYYA RAEGREIISN LAKASGLAHM IATMRPDIDH VDEYVRNTTA RAFSVVASAL
550 560 570 580 590 600
GVPALLPFLK AVCRSKKSWQ ARHTGVRIIQ QIALLLGCSI LPHLKNLVDC IGHGLEDEQQ
610 620 630 640 650 660
KVRIMTALSL SALAEAATPY GIEAFDSVLK PLWSGVQRHR GKSLAAFLKA TGFIIPLMEP
670 680 690 700 710 720
EYASHFTRRI MKILLREFNS PDEEMKKIVL KVVSQCASTD GVTPEYLRTD VLPEFFHCFW
730 740 750 760 770 780
SRRMASDRRS YKQVVETTVV LAQQVGSRQI VERVVNNFKD ESEPYRKMTA ETVDKVIGSL
790 800 810 820 830 840
GVSEIDERLE ELLLDGVLFA FQEQSVEEKV ILTCFSTVVN ALGTRCKPYL PQIVSTILYR
850 860 870 880 890 900
LNNKSANVRE QAADLVSSIT IVLKACGEEA LMRKLGVVLY EYLGEEYPEV LGSILGAIKA
910 920 930 940 950 960
IVSVVGMSSM QPPIRDLLPR LTPILRNRHE KVQENTIDLV GKIADRGSEY VSAREWMRIC
970 980 990 1000 1010 1020
FELIDMLKAH KKSIRRAAVN TFGYISKAIG PQDVLATLLN NLKVQERQNR VCTTVAIAIV
1030 1040 1050 1060 1070 1080
AETCMPFTVV PALMADYRTP EMNVQNGVLK SLAFMFEYIG EQARDYVYAI TPLLADALMD
1090 1100 1110 1120 1130 1140
RDAVHRQTAA SVIKHLSLGC VGLGVEDAMI HLLNILWPNI LEESPHVINA VREGIDGIRN
1150 1160 1170 1180 1190 1200
CIGVGPIMAY LVQGLFHPSR KVRNTYWTSY NSAYVQSADA MVPYYPHVDD DQFNNYDMKT
LHICI