Q10159

PR
Gene name
myh1 (myh, SPAC26A3.02)
Protein name
Adenine DNA glycosylase
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC26A3.02
EC number
3.2.2.31: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

221-325 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10159

Entry ID Method Resolution Chain Position Source
AF-Q10159-F1 Predicted AlphaFoldDB

6 variants for Q10159

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3335040_G_A 17 E>K No Jeffares_SNPs
I_3335170_A_G 60 Q>R No Jeffares_SNPs
I_3336002_A_G 290 H>R No Jeffares_SNPs
I_3336316_A_G 395 I>V No Jeffares_SNPs
I_3336487_G_A 452 A>T No Jeffares_SNPs
I_3336499_G_A 456 V>I No Jeffares_SNPs

No associated diseases with Q10159

6 regional properties for Q10159

Type Name Position InterPro Accession
conserved_site Helix-hairpin-helix motif 134 - 162 IPR000445
domain HhH-GPD domain 63 - 224 IPR003265
conserved_site Endonuclease III-like, iron-sulphur cluster loop motif 225 - 245 IPR003651
binding_site Endonuclease III, iron-sulphur binding site 226 - 242 IPR004035
conserved_site Endonuclease III-like, conserved site-2 135 - 165 IPR004036
domain Adenine DNA glycosylase, C-terminal 297 - 430 IPR029119

Functions

Description
EC Number 3.2.2.31 Hydrolyzing N-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.
adenine/guanine mispair binding Binding to a double-stranded DNA region containing an A/G mispair.
metal ion binding Binding to a metal ion.
oxidized purine DNA binding Binding to a DNA region containing an oxidized purine residue.
purine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.

5 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
base-excision repair, AP site formation The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
depurination The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDSNHSLDL HSYTQLEVER FRESLIQFYD KTKRILPWRK KECIPPSEDS PLEDWEQPVQ
70 80 90 100 110 120
RLYEVLVSEI MLQQTRVETV KRYYTKWMET LPTLKSCAEA EYNTQVMPLW SGMGFYTRCK
130 140 150 160 170 180
RLHQACQHLA KLHPSEIPRT GDEWAKGIPG VGPYTAGAVL SIAWKQPTGI VDGNVIRVLS
190 200 210 220 230 240
RALAIHSDCS KGKANALIWK LANELVDPVR PGDFNQALME LGAITCTPQS PRCSVCPISE
250 260 270 280 290 300
ICKAYQEQNV IRDGNTIKYD IEDVPCNICI TDIPSKEDLQ NWVVARYPVH PAKTKQREER
310 320 330 340 350 360
ALVVIFQKTD PSTKEKFFLI RKRPSAGLLA GLWDFPTIEF GQESWPKDMD AEFQKSIAQW
370 380 390 400 410 420
ISNDSRSLIK KYQSRGRYLH IFSHIRKTSH VFYAIASPDI VTNEDFFWIS QSDLEHVGMC
430 440 450 460
ELGLKNYRAA LEIKKRKVTS LSNFKEPKLT SARRIVTKAE C