Q10078

PR
Gene name
ppk13 (SPAC3H1.13)
Protein name
Serine/threonine-protein kinase ppk13
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3H1.13
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

36-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

212-244 (Activation loop from InterPro)

Target domain

32-344 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10078

Entry ID Method Resolution Chain Position Source
AF-Q10078-F1 Predicted AlphaFoldDB

4 variants for Q10078

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1965191_A_G 7 N>D No Jeffares_SNPs
I_1965449_G_A 80 D>N No Jeffares_SNPs
I_1965488_A_T 93 S>C No Jeffares_SNPs
I_1965859_C_T 203 H>Y No Jeffares_SNPs

No associated diseases with Q10078

3 regional properties for Q10078

Type Name Position InterPro Accession
domain Protein kinase domain 32 - 344 IPR000719
active_site Serine/threonine-protein kinase, active site 190 - 202 IPR008271
binding_site Protein kinase, ATP binding site 38 - 61 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Endoplasmic reticulum
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of vacuole fusion, non-autophagic Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.
signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
vacuolar protein processing Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQNLWKNALD TLSPYISNLF DNDVVCINNE RYRIQKLLGE GGFAFVYLVQ NVSNEKLYAL
70 80 90 100 110 120
KKIKCSFGNK GIKKAMKEAD YHRKFKSNYL LKSYTHQLVK EADGSEFVYI LFPYFAKGSV
130 140 150 160 170 180
AQVIRNCDIE GSYISEKRIL VWCSCLCKAL QYLHENVAGD SPKQPEVNDL IMFDEPQVPQ
190 200 210 220 230 240
NTSNNNLVSY IHGDIKPDNL LLHENSREIV LTDFGSICLV PIFASNNSEA IAIQDKASEN
250 260 270 280 290 300
CTMPFRAPEL FHVKAGSTIT EKADIWSFGC TLYTIMFHAS PFEREVSQGG SLALAVCNAQ
310 320 330 340
YSFPRKHPYS TLLCEIVEAC LQREPNKRPS ARELLSKIDL QINQ