Q10056

PR
Gene name
shk2 (SPAC1F5.09c)
Protein name
Serine/threonine-protein kinase shk2
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1F5.09c
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-327 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

451-474 (Activation loop from InterPro)

Target domain

309-566 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q10056

Entry ID Method Resolution Chain Position Source
AF-Q10056-F1 Predicted AlphaFoldDB

2 variants for Q10056

Variant ID(s) Position Change Description Diseaes Association Provenance
I_273789_A_G 213 Y>C No Jeffares_SNPs
I_273888_C_T 246 T>M No Jeffares_SNPs

No associated diseases with Q10056

6 regional properties for Q10056

Type Name Position InterPro Accession
domain CRIB domain 128 - 185 IPR000095
domain Protein kinase domain 309 - 566 IPR000719
domain Pleckstrin homology domain 23 - 127 IPR001849
active_site Serine/threonine-protein kinase, active site 430 - 442 IPR008271
binding_site Protein kinase, ATP binding site 315 - 343 IPR017441
domain p21 activated kinase binding domain 127 - 171 IPR033923

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lipid binding Binding to a lipid.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
plasma membrane fusion involved in cytogamy The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLSVRGVPV EIPSLKDTKK SKGIIRSGWV MLKEDKMKYL PWTKKWLVLS SNSLSIYKGS
70 80 90 100 110 120
KSESAQVTLL LKDIQKVERS KSRTFCFKLR FKSSTKNFEI QACELSVADN MECYEWMDLI
130 140 150 160 170 180
SSRALASKVS SPMNPKHQVH VGIDNEGNYV GLPKEWILLL QSSSITKQEC MEEPKAVIQA
190 200 210 220 230 240
LDFYSKQLDT TSETKDSFSF CKETLPRSST TSYSIRDADK HHKLTTSGVT KMNITERCKP
250 260 270 280 290 300
KTTIQTDKKH IIRPFIEDKS HVESIMTGKV TKVPVKADSK NTLSRRMTDR QALAMLKDSV
310 320 330 340 350 360
TSHDPVEYFN VKHKLGQGAS GSVYLAKVVG GKQLGIFDSV AIKSIDLQCQ TRKELILNEI
370 380 390 400 410 420
TVMRESIHPN IVTYLDSFLV RERHLWVVME YMNAGSLTDI IEKSKLTEAQ IARICLETCK
430 440 450 460 470 480
GIQHLHARNI IHRDIKSDNV LLDNSGNIKI TDFGFCARLS NRTNKRVTMV GTPYWMAPEV
490 500 510 520 530 540
VKQNEYGTKV DIWSLGIMII EMIENEPPYL REDPIRALYL IAKNGTPTLK KPNLVSKNLK
550 560 570 580
SFLNSCLTID TIFRATAAEL LTHSFLNQAC PTEDLKSIIF SRKANTHIN