Q0W5Q9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
KEGG Pathway
rci:RCIX939
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

454-527 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0W5Q9

Entry ID Method Resolution Chain Position Source
AF-Q0W5Q9-F1 Predicted AlphaFoldDB

No variants for Q0W5Q9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0W5Q9

No associated diseases with Q0W5Q9

3 regional properties for Q0W5Q9

Type Name Position InterPro Accession
domain Threonyl/alanyl tRNA synthetase, SAD 687 - 730 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 81 - 587 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 74 - 743 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDKEIKKLM KPEFAKNYEK YYPVQTLTAM GYHRRVCKKC GRGFWTQVER DFCDEAECSG
70 80 90 100 110 120
GYRFIGESLT RKKFEYKEAW DTYVKTFEQW GYVPLERYPT VCRWYEDLYF VAAGINDFQP
130 140 150 160 170 180
YVVSGEIEPP ARAVLEPQFC LRFNDIDNVG ITGRHYTGFI MVGQHTFNTP EKHVYFKEEG
190 200 210 220 230 240
IGQIQHFLTQ GLGIPAHEIV FHEDVWAGGG NFGPSIEYFS RGLELGNQVY MQYEQTPDGG
250 260 270 280 290 300
FKELRTKVID MGAGLERWAW FSQGCPMSYD ATFPKTMEFI YNKTGYRADP VFHAKFAKYA
310 320 330 340 350 360
GILNVEEIED VGSAWNDVAK SMEMDLGELK DMVYKIRAQY VLADHTRSLL VAIHDGALPS
370 380 390 400 410 420
NVGGGYNLRN LLRRCWSLID QYQWDIDLND IFRSHIDEFG SWYTELKDYG SLFDIIDVER
430 440 450 460 470 480
KRYEESRRKS KDIIKRMVKA KETLTADKLV ELYDSQGISP ELIKEAKPDV VIPEDFYARV
490 500 510 520 530 540
QARHDAKATR KIEVNETQGL PKTEPMYYEK PREFKFEANV VKLLTPTKLV LDRTLFYPLG
550 560 570 580 590 600
GGQAGDTGFV NGIKVKDVYK QDGVIIHVLE SPMPPDTTKV IGEVDEARRR ILAAHHSATH
610 620 630 640 650 660
IVNYAARKVL GDHVWQAGAE KTPEKARLDI THYESLTFQQ LQEIERVAND LAMKQIPVVV
670 680 690 700 710 720
REMSRTEAEM EYSMRIYQGG AVPGKILRII VIDGYDVEAC GGIHVDNTSK VGFIKMLSSE
730 740 750 760 770 780
RIQDGVVRLE FKSLDNAVSE IQHHESILRE VSDLWGVGYD DIPKTAQRFF NEWKELGKKN
790 800 810 820 830 840
KELQAELVQQ TIAAALGKPG DTVDVVVTGA DFGTLMKAVG SFKKEFKGRT VIFRGDNFAY
850 860 870
GYSDLINVKE KLAEGYVNVD GSEHEAKAFK AKPKA