Q0W3X9

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
KEGG Pathway
rci:RCIX1693
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0W3X9

Entry ID Method Resolution Chain Position Source
AF-Q0W3X9-F1 Predicted AlphaFoldDB

No variants for Q0W3X9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0W3X9

No associated diseases with Q0W3X9

5 regional properties for Q0W3X9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 292 - 501 IPR002314
domain Anticodon-binding 523 - 615 IPR004154
domain Aminoacyl-tRNA synthetase, class II 212 - 513 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 138 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 521 - 613 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQLLLIHSDF IEYEVKKSTP VAEKIEDAVR SGRMEEALTA FAAVEKPDES NPQYVIEKGL
70 80 90 100 110 120
EAIIKVAEQV KTTRVMLYPY AHLSANLSSP KMAVEVLKGL EAALKGKGFE VARAPFGWYK
130 140 150 160 170 180
AFTIKCKGHP LSELSRTIRP EGVEAVSVTP AVAAEKPEVV SEAVKAEEKL KSYFYILDVD
190 200 210 220 230 240
GQLKDPKTFD YKGHDKLKAF VDYEMAKKRA VDREPPHVEL MRRLELADYE PGSDPGNMRW
250 260 270 280 290 300
YPKGRAMKNM LEQFVLSEAA KKGAMEVETP IMYDMEHPTL KKYLDRFPAR QYTVIADKKN
310 320 330 340 350 360
LFLRFAACFG QFLMNHDMTI SYRNLPLKMI ELTRYSFRKE QRGELVGLRR LRAFTMPDMH
370 380 390 400 410 420
TLCTDMDGAI KEFGDQYEMC INTLDTIGID IKTDYEVAIR FTKDFYNNNT PFIQSLVKRA
430 440 450 460 470 480
GKPVIVEMWE ERFFYFVLKF EFNYIDSLNK ASALSTVQID VENAERYDIN YVDQNGNRQR
490 500 510 520 530 540
PIILHCSPSG AIERCIYGLL EKEAMESEKG AVPMLPVWLS PTQVRIVTIS EKHVPFAEAL
550 560 570 580 590 600
ADRMCNVRVD IDDREETVGK KIRDAGKEWI PYVVTIGDAE MNGDKIPVVV RAESQQNKPA
610 620 630 640
KVEMTVEELV ERIHKETACL PYRPLPVVRS LAKRPKFVGS I