Q0VSA8

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
KEGG Pathway
abo:ABO_0492
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VSA8

Entry ID Method Resolution Chain Position Source
AF-Q0VSA8-F1 Predicted AlphaFoldDB

No variants for Q0VSA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0VSA8

No associated diseases with Q0VSA8

5 regional properties for Q0VSA8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 16 - 600 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 644 - 805 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 866 - 929 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 599 - 736 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIMDKTYQPD RIEQSWYENW EQAGHFKPSG QGDPFCIMIP PPNVTGSLHM GHAFQDTIMD
70 80 90 100 110 120
TLVRYRRMQG RNTLWQVGTD HAGIATQMVV ERKLAGEGTN RHELGREKFL DKVWEWKRES
130 140 150 160 170 180
GGTITRQLRR MGASVDWTRE RFTMDDGLSN AVREVFVRLH KEGLIYRGKR LVNWDPALHT
190 200 210 220 230 240
AISDLEVENV EEQGHMWHFR YPLSDGSGHL VVATTRPETM LGDTAVAVHP QDPRYKDMIG
250 260 270 280 290 300
KSIRLPLADR NIPIIADDYV DPDFGSGCVK ITPAHDFNDY EVGKRHDLPM INILTIDAAL
310 320 330 340 350 360
NDEVPEGYRG LDRVEARKKV VDDLDALGLL EKVDDHTLQV PRGDRSGVVI EPYLTDQWFV
370 380 390 400 410 420
AVEELAKPAI AAVENGDIQF VPKNYENMYF SWMRDLQDWC ISRQLWWGHR IPAWYDADGN
430 440 450 460 470 480
VYVGRDEEEV RAENNLGDTP LSQDDDVLDT WFSSALWTFS TLGWPDDTDA LRTFHPTDVL
490 500 510 520 530 540
VTGFDIIFFW VARMIMMTLK FTDQVPFKKV YVHGLVRDND GQKMSKSKGN VLDPLDMIDG
550 560 570 580 590 600
ITLDALIDKR TKGLMQPQKE KQITKRTNKD FPDGINPYGT DALRFTFLSL ASTGRDIKWD
610 620 630 640 650 660
MGRIEGYRNF CNKIWNAARY VMMNTEGEDC GIDTDSEVEL SLADRWIISA LQRAELEVSE
670 680 690 700 710 720
ALDSFRFDVA SHAAYEFIWN EYCDWYLELS KPVLWGDEYS DAQKRGTRRT LVTVLEAILR
730 740 750 760 770 780
MAHPFMPFIT EEIWQKVGPL AGKASAAGKG EKTDTIMLQP FPASEPAKID TNAETGAEWV
790 800 810 820 830 840
KAVISAVRNI RGEMGIPLGK ALPIYLHNGK DSDKALLDAN RVFLCKLAKL ESITWLTAED
850 860 870 880 890 900
SAPASATALV GDMEILVPMA GLIDKEAEIE RLSKEIEKLR KEVGRAEGKL KNPKFVDKAP
910 920 930
QAVVDKEKAK LDDYRSQLAK LEEQLEKIKY L