Q0VP51

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
KEGG Pathway
abo:ABO_1599
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

519-599 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VP51

Entry ID Method Resolution Chain Position Source
AF-Q0VP51-F1 Predicted AlphaFoldDB

No variants for Q0VP51

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0VP51

No associated diseases with Q0VP51

7 regional properties for Q0VP51

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 22 - 33 IPR001412
domain tRNA-binding domain 584 - 686 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 549 - 686 IPR004495
domain Methionyl/Leucyl tRNA synthetase 15 - 401 IPR015413
domain Methioninyl-tRNA synthetase core domain 14 - 376 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 389 - 400 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 386 - 524 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEIDAVPMSD TPRKILVTSA LPYANGPIHL GHLLEYIQTD IWVRFQKLRG QQCIYVCADD
70 80 90 100 110 120
AHGTAIMLKA EENGVTPEQQ IAQVKADHER DFADFQVNFD NYYSTHSPEN RALSEMVFQR
130 140 150 160 170 180
NKDAGYILEK TITQLYDPQK GMFLADRFVK GTCPKCKSED QYGDNCEVCG ATYTPAELIE
190 200 210 220 230 240
PYSSVSGATP VEKETTQLFF DLPKFEALLR EWTRSGALQE QVANKLQEWI EDLQPWDISR
250 260 270 280 290 300
EAPYFGFEIP GYPGKYFYVW LDAPIGYMAS FQNYCDREGL SFDDYWGKES TAELYHFIGK
310 320 330 340 350 360
DIINFHGLFW PAMLDGAGLR KPTAIYSHGF VTVNGAKMSK SRGTFIKART YLDHLSPEYL
370 380 390 400 410 420
RYYFAAKLSS RVDDFDLNLE DFAQRVNSDL VGKLVNIASR TGNFVKKFGG TLSTELDNMM
430 440 450 460 470 480
LVREVQEAGP RIADFYEKRE FGKAMREIMA LADHANVYIA DKAPWSLSKE EGKEQEVLAI
490 500 510 520 530 540
CSTAINVFRL LVIYLKPVLP ALAERAEAFM QVEPLTWADS EQLLLGHEIA KFKPLLSRVD
550 560 570 580 590 600
MAQVESMLED SKESTPAPAA AKPKKAATQK ADAADNDETI SIDDFLKVKL RVARVAKAAH
610 620 630 640 650 660
VDGADKLLQL TLDVGELGQR NVFAGIKARY APEELEGKLV VLVANLAPRK MKFGISEGMV
670 680
LAAGPGGDDI HILSPDSGAE PGMEVR