Q0VEJ0
Gene name |
Cep76 |
Protein name |
Centrosomal protein of 76 kDa |
Names |
Cep76 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:225659 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0VEJ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0VEJ0-F1 | Predicted | AlphaFoldDB |
14 variants for Q0VEJ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389466629 | 112 | V>* | No | EVA | |
| rs3389507821 | 190 | D>G | No | EVA | |
| rs3389520466 | 232 | L>H | No | EVA | |
| rs3408592961 | 303 | S>* | No | EVA | |
| rs226381680 | 329 | A>T | No | EVA | |
| rs3408780400 | 348 | Y>* | No | EVA | |
| rs3408312574 | 352 | P>A | No | EVA | |
| rs3389509002 | 381 | A>S | No | EVA | |
| rs3389418933 | 445 | E>V | No | EVA | |
| rs3389517984 | 458 | C>Y | No | EVA | |
| rs3389517986 | 459 | V>I | No | EVA | |
| rs3389509046 | 470 | Q>H | No | EVA | |
| rs3389505996 | 470 | Q>R | No | EVA | |
| rs3389509586 | 584 | R>G | No | EVA |
No associated diseases with Q0VEJ0
No regional properties for Q0VEJ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q0VEJ0 | |||
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of centriole replication | Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TAP6 | CEP76 | Centrosomal protein of 76 kDa | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLPPEKASE | LKQLIHQQLS | KMDVHGRIRE | ILAETIREEL | APDQQHLSTE | DLIKALRRRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIDDVMKELN | FVTDSVDQEL | PSSPKQTVGF | DKQSTLKKTN | VDPTRRYLYL | QVLGGKAFLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLQEPEPLPG | QICSTFTLCL | HYRNQRFRSK | PVPCACEPDF | HDGFLLEVHR | ESLGDGTRMA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSTTMLSISD | PIHMVLIKTD | IFGETTLVAS | YFLEWRSVLG | SENGVTNLTV | ELMGVGTESK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSVGILNIKL | EMYPPLSQTL | SQEVVNTQLA | LERQKTAEKE | RLFLVYAKQW | WREYLQIRPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HNSRLVKIFA | QDENGINRPV | CSYVKPLRAG | RLLDTPRQAA | RFVNVLGYER | APVIGGGGKQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EQWCTLLAFL | CRNKGDCEDH | ANLLCSLLLG | YGLEAFVCVG | TKAKGAPHAW | VMTCGTDGTI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MFWESLTGHR | YIHKPTNPDG | PPLAEQPKPL | YPYRTIGCVF | NHQMFLGNCQ | PSDAVETCIF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLNDESKWKP | MSEEAIKSVC | APGATTSLPP | FPPLCASTID | ASVTSNEIEM | QLRLLVSEHR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDLGLTTVWE | DQLSYLLSPA | LASYEFERTT | SISAGNEEFQ | DAIRRAVPDG | HTFKGFPIHF |
| 610 | 620 | 630 | 640 | 650 | |
| VYRNARRAFA | TCLRSPFCEE | IICCRGDQVR | LAVRVRVFTY | PESACAVWIM | FACKYRSVL |