Q0VA61

PR
Gene name
hyou1
Protein name
Hypoxia up-regulated protein 1
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:779444
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

546-620 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VA61

Entry ID Method Resolution Chain Position Source
AF-Q0VA61-F1 Predicted AlphaFoldDB

No variants for Q0VA61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0VA61

No associated diseases with Q0VA61

1 regional properties for Q0VA61

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 368 - 382 IPR018181

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum chaperone complex A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1.
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9JKR6 Hyou1 Hypoxia up-regulated protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MRPLVCVFTM FLLALLSSNT ESVAVMSVDM GSEWMKIAIV KPGVPMEIVL NKESRRKTPV
70 80 90 100 110 120
AIALKENERL FGDSALGMAV KNPKVTFRYF QDLLGKRADN PHVKAFEARF PEYQLVKDEH
130 140 150 160 170 180
RETVLFKLSE ELTYSPEELL GMMLNYSRSL AEEFAEQPVK DVVITVPAFF NQAERRAVLQ
190 200 210 220 230 240
AAQLSDLKVL QLINDNTAVA LNYGVFRRKD INATAQNIMF YEMGSRSTIC TIVTYQSVKT
250 260 270 280 290 300
KDSGMQPQLQ IRGVGFDRTL GGIEMDLRLR DHLAKLFNEQ KKSKKDVREN QRAMSKLLKE
310 320 330 340 350 360
ANRVKTILSA NNDHMAQIEG LMDDIDFKAK VTRQELEDLC ADLFNRVSAP VQHALSSAEM
370 380 390 400 410 420
KMEEIDQVIL VGGATRVPKV QELLLKVVGK EELGKNINAD EAAAMGAVYQ AAALSKAFKV
430 440 450 460 470 480
KPFIVRDAAI FPIQVEFTRE VEEEDHSKSL KHNKRILFQR LAPYPQRKVI TFNRYTDNFA
490 500 510 520 530 540
FSINYGDLSY LGPDDLKVFG SLNLTTVKLN GVGESFQKRS DYESKGIKAH FNMDESGLLT
550 560 570 580 590 600
LDRVEAVFET VVDEKPEQES TLTKLGNTIS SLFGGGSSVP ETKENATDSV QEEDEVPTEP
610 620 630 640
TKEEEQESAD AADKQKDKEK GTTATNEEEE GKKEEEKSEP QEE