Q0UXL8

PR
Gene name
MSH3 (SNOG_03496)
Protein name
DNA mismatch repair protein MSH3
Names
MutS protein homolog 3
Species
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KEGG Pathway
pno:SNOG_03496
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0UXL8

Entry ID Method Resolution Chain Position Source
AF-Q0UXL8-F1 Predicted AlphaFoldDB

No variants for Q0UXL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0UXL8

No associated diseases with Q0UXL8

5 regional properties for Q0UXL8

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 889 - 1082 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 219 - 344 IPR007695
domain DNA mismatch repair protein MutS, core 538 - 872 IPR007696
domain DNA mismatch repair protein MutS, connector domain 360 - 515 IPR007860
domain DNA mismatch repair protein MutS, clamp 710 - 796 IPR007861

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPKSSQSSQ GLSQRSKQQT ISSFFTPKPS QTPKAPPKPA ALAVPNGADQ DDDDDEDEDI
70 80 90 100 110 120
APPRQLTPAR KRSIDEQHED EEAGRSSPPK RVRVANDEPR PSLGNASATT LNAAKPPKIT
130 140 150 160 170 180
ERTSKFLFSS SPVVRDETDA KDDAAATQKL REKLHEKFVK KLGRPDSFAE LRRRNKVISE
190 200 210 220 230 240
DNGNGEEGEG EEDEEEEEPA PKPTKGRKGA ATKKTSKLTP MELQYLDIKR KHMDTVIVME
250 260 270 280 290 300
VGYKFKFFGE DARTASKELG IVCIPGKFRY DEHPSEAHYD RFASASFPVH RLQVHVKRLV
310 320 330 340 350 360
KANHKVGVVR QLETAALKAA GNNRNTPFVR KLTNLYTKGT YVDDIEGLET PTAGAQATGY
370 380 390 400 410 420
LLCVTETNAK GWGTDEKVQV GLVAVQPATG DIIYDDFEDG FMRSEIETRL LHIAPAEFLI
430 440 450 460 470 480
VGDLSKATDK LIHHLSASKT NVFGDRSRVE RVEKPKTMAA QAYSHISNFY ADKMKSSQEG
490 500 510 520 530 540
GSEQGAILDK VHQLSEHVTI CLSAMITYLS DYALEHVFDL TKYFQPFSAR SYMLLNGNTL
550 560 570 580 590 600
SSLEIYQNQT DYTSKGSLFW TMDRTKTRFG QRLLRKWVGR PLIDKERLEE RIAAVEELKE
610 620 630 640 650 660
GEHTIAVDKV KFLLGKIKTD LEKVLIRIYY KKCSRPELLA ALQILQDIAS QYLSAKTPEQ
670 680 690 700 710 720
SGFSSILLSE AVSNVPKIYE DVNSFLEKIN AKAAKDDDKY GFFREEFEAE DINDLKLSIA
730 740 750 760 770 780
SVEDDLNTHR KDAAAKLGKT KVDYVTVAGI EYLIEVKRKS VEEKKVPASW QQISATKTTL
790 800 810 820 830 840
RFHTPEVKRM LQERDQYKES LAAACDTAFK RLLDDIAAKY QSLRDCVSSL ATLDALLSLA
850 860 870 880 890 900
TLANQPGYVK PTFVETTELD IVGGRHPMVE QLLLDAYVPN DVHLSGDATR ALLVTGPNMG
910 920 930 940 950 960
GKSSYVRSAA LIAIMGQIGS YVPAESAKLG MLDAVFTRMG ALDNMLKGES TFMVELNETA
970 980 990 1000 1010 1020
DILRSATSRS LIILDELGRG TSTFDGVAIA EAVLDYVIRD VGALTLFITH YQHLARLQDR
1030 1040 1050 1060 1070 1080
FNGELKNVHM SFEERDGGKE VVFLYEVAEG TSHRSYGLNV ARLAKVPEKV IETAEVKSSE
1090 1100 1110
LEESMGISRV ANMARMVKGL LEDGGEEGLE RLIEGIEQL